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Keap1-Nrf2 Interaction Probe, ML334-Calbiochem

品牌
Sigma-Aldrich
货号
5.05987
规格纯度
A cell-permeable, direct, non-covalent inhibitor of Keap1-Nrf2 protein-protein interaction (Kd = 1 μM) that causes the dissociation of Nrf2 from keap1 in the cytosol.
价格
2151.18 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
Keap1-Nrf2 Interaction Probe, ML334-Calbiochem
(1S,2R)-2-((S)-1-((1,3-dioxoisoindolin-2-yl)methyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)cyclohexanecarboxylic acid, (SRS)-LH601, Nrf Activator VI
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A cell-permeable tetrahydroisoquinoline derivative that acts as a direct, non-covalent inhibitor of Keap1 - Nrf2 (Kelch-like ECH-associated protein 1 - nuclear factor erythroid 2-related factor 2) protein - protein interaction (Kd= 1 ?M) that causes the dissociation of Nrf2 from keap1 in the cytosol. Exhibits ARE-inducing activity (EC50= 18 ?M in U2OS Keap1-Nrf2 functional assay) and promotes Nrf2 translocation to the nucleus (EC50= 12 ?M). Has good solubility in aqueous buffers (>100 ?M in phosphate buffered saline).
A cell-permeable tetrahydroisoquinoline derivative that acts as a direct, non-covalent inhibitor of Keap1 - Nrf2 (Kelch-like ECH-associated protein 1 - nuclear factor erythroid 2-related factor 2) protein - protein interaction (Kd= 1 ?M) that causes the dissociation of Nrf2 from keap1 in the cytosol. Exhibits ARE-inducing activity (EC50= 18 ?M in U2OS Keap1-Nrf2 functional assay) and promotes Nrf2 translocation to the nucleus (EC50= 12 ?M). Has good solubility in aqueous buffers (>100 ?M in phosphate buffered saline).

Please note that the molecular weight for this compound is batch-specific due to variable water content.

生化/生理作用

Primary Target
Keap1–Nrf2
Reversible: yes

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Hu, L., et al, 2013,Bioorg. Med. Chem. Lett.23,3039.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C26H26N2O5
分子量 446.50

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 powder
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
protect from light
颜色 cream
溶解性 DMSO: 100 mg/mL
储存温度 ?20℃

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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