半岛bd体育手机客户端 说明
一般描述
A cell-permeable tetrahydroisoquinoline derivative that acts as a direct, non-covalent inhibitor of Keap1 - Nrf2 (Kelch-like ECH-associated protein 1 - nuclear factor erythroid 2-related factor 2) protein - protein interaction (Kd= 1 ?M) that causes the dissociation of Nrf2 from keap1 in the cytosol. Exhibits ARE-inducing activity (EC50= 18 ?M in U2OS Keap1-Nrf2 functional assay) and promotes Nrf2 translocation to the nucleus (EC50= 12 ?M). Has good solubility in aqueous buffers (>100 ?M in phosphate buffered saline).
A cell-permeable tetrahydroisoquinoline derivative that acts as a direct, non-covalent inhibitor of Keap1 - Nrf2 (Kelch-like ECH-associated protein 1 - nuclear factor erythroid 2-related factor 2) protein - protein interaction (Kd= 1 ?M) that causes the dissociation of Nrf2 from keap1 in the cytosol. Exhibits ARE-inducing activity (EC50= 18 ?M in U2OS Keap1-Nrf2 functional assay) and promotes Nrf2 translocation to the nucleus (EC50= 12 ?M). Has good solubility in aqueous buffers (>100 ?M in phosphate buffered saline).
Please note that the molecular weight for this compound is batch-specific due to variable water content.
生化/生理作用
Primary Target
Keap1–Nrf2
Reversible: yes
包装
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Hu, L., et al, 2013,Bioorg. Med. Chem. Lett.23,3039.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
经验(实验)分子式 | C26H26N2O5 |
分子量 | 446.50 |
半岛bd体育手机客户端 性质
质量水平 | 100 |
测定 | ≥98% (HPLC) |
形式 | powder |
manufacturer/tradename | Calbiochem? |
储存条件 | OK to freeze protect from light |
颜色 | cream |
溶解性 | DMSO: 100 mg/mL |
储存温度 | ?20℃ |
安全信息
储存分类代码 | 11 - Combustible Solids |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich