KDM4A/KDM4B Inhibitor, NSC636819-Calbiochem

品牌

Sigma-Aldrich

货号

5.31996

包装型号

10 MG

规格纯度

价格

1595.89 元 *本价格含增值税费

促销

数量

- +

半岛bd体育手机客户端名称：

KDM4A/KDM4B Inhibitor, NSC636819-Calbiochem
JMJD2 Inhibitor, Jumonji C-containing Histone Lysine Demethylase Inhibitor

半岛bd体育手机客户端介绍：

半岛bd体育手机客户端说明

一般描述

A cell permeable dinitrobenzene derivative that acts as a competitive inhibitor of KDM4A (IC₅₀= 6.4 ?M; K_i= 5.5 ?M) and KDM4B (IC₅₀= 9.3 ?M; K_i= 3.0 ?M) and completely blocks their demethylating activity toward H3K9me3 (~ 5 ?M). Exhibits much reduced activities against KDM4D and KDM4E. Effectively induces apoptosis in LNCaP cells (IC₅₀= 16.5 ?M after 3-day culture), but does not affect normal PNT2 cells (~ 5 to 20 ?M over 6 days). Shown to up-regulate RB1 and CDH1 tumor suppressor genes and down-regulates IGF1R, FGFR3, CCNE2, AURKA, and AURKB oncogenes.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
A cell permeable dinitrobenzene derivative that acts as a competitive inhibitor of KDM4A (IC₅₀= 6.4 ?M; K_i= 5.5 ?M) and KDM4B (IC₅₀= 9.3 ?M; K_i= 3.0 ?M) and completely blocks their demethylating activity toward H3K9me3 (~ 5 ?M). Exhibits much reduced activities against KDM4D and KDM4E. Effectively induces apoptosis in LNCaP cells (IC₅₀= 16.5 ?M after 3-day culture), but does not affect normal PNT2 cells (~ 5 to 20 ?M over 6 days). Shown to up-regulate RB1 and CDH1 tumor suppressor genes and down-regulates IGF1R, FGFR3, CCNE2, AURKA, and AURKB oncogenes.

生化/生理作用

Cell permeable: yes
Primary Target
KDM4A/B
Reversible: yes

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Chu, C.H., et al. 2014.Journ. Med. Chem.57,5975.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₂₂H₁₂Cl₄N₂O₄
分子量	510.15

半岛bd体育手机客户端性质

质量水平	100
测定	≥97% (HPLC)
形式	solid
效能	3.0 μM K_i
manufacturer/tradename	Calbiochem^?
储存条件	OK to freeze protect from light
颜色	brown
溶解性	DMSO: 10 mg/mL
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable