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K-Ras Inhibitor, SAH-SOS1A-Calbiochem

品牌
Sigma-Aldrich
货号
5.38092
包装型号
规格纯度
价格
3531.36 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
K-Ras Inhibitor, SAH-SOS1A-Calbiochem
K-Ras Inhibitor, SAH-SOS1 A
K-Ras Inhibitor, SAH-SOS1 A
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A cell-permeable hydrocarbon-stapled, α-helical peptide that mimics the native son of sevenless 1 (SOS1) helical domain (amino acids 929-944) with additional Arg-Arg tag for better cell permeability. Binds to wild-type and mutant KRAS at the SOS1 binding pocket in a sequence-specific manner and disrupts SOS1/KRAS interaction (EC50= 79, 61, 103, 129, 140, and 124 nM for wild-type, G12D, G12V, G12C, G12S, and Q61H mutants, respectively) and blocks their nucleotide association. Reported to engage both GDP-KRAS and GTP-KRAS. Shown to impair the viability of cancer cells bearing G12D, G12C, G12V, G12S, G13D, and Q61H mutations (IC50= 5 - 15 ?M). Also diminishes the viability of HeLa and Colo320-HSR cells expressing wild-type KRAS. Inhibits the activity of MEK1/2, ERK1/2, and Akt in Panc10.05 cells treated with epidermal growth factor. Also shown to completely suppress the phosphorylation of Akt and ERK1/2 inDrosophila melanogasterexpressing V12 mutant form of RAS85D upon RU486 (Cat. No. 475838) treatment.

生化/生理作用

Cell permeable: yes
Reversible: yes
Primary Target
K-Ras

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

序列

Ac-RRFFGIXLTNXLKTEEGN (X=(S)-2-(4′-pentenyl)Ala, stapled)

外形

Supplied as a trifluoroacetate salt.

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Leshchiner, E. S. et al. 2015.Proc. Natl. Acad. Sci. USA.112,1761.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C100H159N27O28
分子量 2187.50

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥95% (HPLC)
形式 solid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
desiccated (hygroscopic)
protect from light
颜色 off-white
溶解性 DMSO: 5 mg/mL
water: 5 mg/mL
储存温度 ?20℃

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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