半岛bd体育手机客户端 说明
一般描述
A cell-permeable, non-toxic, n-octyl ester form of 5-carboxy-8-hydroxyquinoline (IOX1, Cat. No. 420201) that acts as a superior inhibitor of Jumonji C domain histone lysine demethylase. Shown to be about 30 fold more potent than IOX1 (EC50= 3.8 ?M for KDM4A in HeLa cells vs. 100 ?M for IOX1). Inhibits the H3K9 me3 demethylation activity of KDM4C (IC50= 3.9 ?M in ALPHA Screen assay). Exhibits greater stability to hydrolysis in the ALPHA Screen buffer.
A cell-permeable, non-toxic, n-octyl ester form of 5-carboxy-8-hydroxyquinoline (IOX1, Cat. No. 420201) that acts as a superior inhibitor of Jumonji C domain histone lysine demethylase. Shown to be about 30 fold more potent than IOX1 (EC50= 3.8 ?M for KDM4A in HeLa cells vs. 100 ?M for IOX1). Inhibits the H3K9 me3 demethylation activity of KDM4C (IC50= 3.9 ?M in ALPHA Screen assay). Exhibits greater stability to hydrolysis in the ALPHA Screen buffer.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
生化/生理作用
Cell permeable: yes
Primary Target
KDM4
Reversible: yes
包装
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Schiller, R., et al. 2014.ChemMedChem.9,566.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C18H23NO3 |
| 分子量 | 301.38 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze protect from light |
| 颜色 | gray-green |
| 溶解性 | DMSO: 5 mg/mL |
| 储存温度 | ?20℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
