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JAK2 Inhibitor X, FLLL32-Calbiochem

品牌
Sigma-Aldrich
货号
5.30153
规格纯度
A cell permeable analog of curcumin that acts as a specific inhibitor of JAK2 (~ 5 μM) and blocks STAT3 phosphorylation in MDA-MB-231 and PANC-1 cancer cells.
价格
2862.54 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
JAK2 Inhibitor X, FLLL32-Calbiochem
STAT3 Signaling Inhibitor, FLLL32
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A cell permeable diketone analog of curcumin that acts as a specific inhibitor of JAK2 (~ 5 ?M) and blocks STAT3 phosphorylation in MDA-MB-231 breast and PANC-1 pancreatic cancer cells. However, it does not affect STAT3 phosphorylation in normal human mammary epithelial cells or human pancreatic duct epithelial cells. Does not block the activity of tyrosine kinases containing SH2 and SH2-SH3 domains and several other kinases, such as Akt2, Cdk2-cyclin D1, EGFR kinase, Met, and EbrB2/Her2 kinase (IC50>100 ?M). Also shown to block DNA binding activity of STAT3. Significantly reduces the viability and invasion capacity of various cancer cells (IC50= 640 nM; 110 nM, 140 nM, 600 nM, 400 nM in PANC-1, HPAC, MDA-MB-231, SK-BR3, and SUM-159 cells, respectively) and induces apoptosis. Shown to significantly reduce tumor burdens in the MDA-MB-231 xenografted mice.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
A cell permeable diketone analog of curcumin that acts as a specific inhibitor of JAK2 (~ 5 ?M) and blocks STAT3 phosphorylation in MDA-MB-231 breast and PANC-1 pancreatic cancer cells. However, it does not affect STAT3 phosphorylation in normal human mammary epithelial cells or human pancreatic duct epithelial cells. Does not block the activity of tyrosine kinases containing SH2 and SH2-SH3 domains and several other kinases, such as Akt2, Cdk2-cyclin D1, EGFR kinase, Met, and EbrB2/Her2 kinase (IC50>100 ?M). Also shown to block DNA binding activity of STAT3. Significantly reduces the viability and invasion capacity of various cancer cells (IC50= 640 nM; 110 nM, 140 nM, 600 nM, 400 nM in PANC-1, HPAC, MDA-MB-231, SK-BR3, and SUM-159 cells, respectively) and induces apoptosis. Shown to significantly reduce tumor burdens in the MDA-MB-231 xenografted mice.

生化/生理作用

Cell permeable: yes
Primary Target
JAK2
Reversible: yes

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Wu, J., et al. 2014.Oncogene33,173.
Onimoe, G., et al. 2012.Invest. New Drugs30,916.
Li, L., et al. 2010.Cancer Res.70,2445.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C28H32O6
分子量 464.55

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 powder
效能 5 μM IC50
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
protect from light
颜色 yellow
溶解性 DMSO: 100 mg/mL
储存温度 2-8℃

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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