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InSolution Aphidicolin-CAS 38966-21-1-Calbiochem

品牌
Sigma-Aldrich
CAS
38966-21-1
货号
5.04744
规格纯度
A 30 mM (1 mg/98 μL) sterile-filtered solution of Aphidicolin in DMSO.
价格
2232.98 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
38966-21-1
InSolution Aphidicolin-CAS 38966-21-1-Calbiochem
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A cell-permeable tetracyclic diterpene antibiotic. Cell synchronization agent. Blocks the cell cycle at the early S-phase. Specific, non-competitive and reversible inhibitor of DNA polymerase α and δ in eukaryotic cells and in some viruses of animal origin. Potentiates apoptosis induced by arabinosyl nucleosides in leukemia cell lines. Also induces apoptosis in HeLaS3 cells, but inhibits vincristine (>Cat. No. 677181)-induced apoptosis in the p53-negative human prostate cancer cell line PC-3.

生化/生理作用

Cell permeable: yes
Primary Target
DNA polymerase α and δ
Reversible: yes

包装

Packaged under inert gas

警告

Toxicity: Irritant (B)

外形

A 30 mM (1 mg/98 ?L) sterile-filtered solution of Aphidicolin (Cat. No. 178273) in DMSO.

重悬

Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C. Use only fresh DMSO for further dilutions.

其他说明

Borner, M.M., et al. 1995.Cancer Res.55,2122.
Poluha, W., et al. 1995.Oncogene10,185.
Urbani, L., et al. 1995.Exp. Cell Res.219,159.Schimke, R.T., et al. 1994.Philos. Trans. R. Soc. London. B. Biol. Sci.345,311.Kuwakado, K., et al. 1993.Biochem. Pharmacol.46,1909.Hubermann, J.A. 1981.Cell23,647.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C20H34O4
分子量 338.48
MDL编号 MFCD00083214

半岛bd体育手机客户端 性质

测定 ≥98% (TLC)
质量水平 100
形式 liquid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light
储存温度 ?70℃
InChI 1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1
InChI key NOFOAYPPHIUXJR-APNQCZIXSA-N

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 2
闪点(F) 188.6 °F - (refers to pure substance)
闪点(C) 87 ℃ - (refers to pure substance)

Sigma-Aldrich

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