半岛bd体育手机客户端 说明
一般描述
A cell-permeable 6-amino-purine based compound that selectively binds to HSP90a (EC50= 5.4 ?M) and inhibits its activity in SKBr3 and MCF-7 breast cancer cells. Exhibits much reduced activity towards other paralogs (EC50= 22.85, 71, and 173 5.4 ?M for HSP90b, GRP94 AND Trap-1, respectively). Selectively depletes cytosolic HER2 and induces its redistribution towards lysosomes and early endosomes (~20 5.4 ?M) without affecting membrane associated HER2. Does not appear to be toxic towards nonmalignant cells.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
A cell-permeable 6-amino-purine based compound that selectively binds to HSP90a (EC50= 5.4 ?M) and inhibits its activity in SKBr3 and MCF-7 breast cancer cells. Exhibits much reduced activity towards other paralogs (EC50= 22.85, 71, and 173 5.4 ?M for HSP90b, GRP94 AND Trap-1, respectively). Selectively depletes cytosolic HER2 and induces its redistribution towards lysosomes and early endosomes (~20 5.4 ?M) without affecting membrane associated HER2. Does not appear to be toxic towards nonmalignant cells.
生化/生理作用
Cell permeable: yes
Primary Target
HSP90a
包装
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Patel, P.D., et al. 2013.Nat. Chem. Biol.9,677.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C20H26FN5O4 |
| 分子量 | 419.45 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze protect from light |
| 颜色 | off-white |
| 溶解性 | DMSO: 100 mg/mL |
| 储存温度 | 2-8℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
