半岛bd体育手机客户端 说明
一般描述
A tertiary N-alkylamine that acts as a pH dependent antagonist of GluN2B-NMDA receptors. Shown to be about 10-fold more potent in ischemic tissue (pH 6.9) than in normal healthy tissue (pH 7.6) (IC50= 190 nM and 1.8 ?M, respectively). Effectively reduces the infarct volume in damaged brain tissue in a murine model of ischemic stroke (at 10 mg/kg, ED50≤ 1 mg/kg) without impairing coordination or motor function. Also displays binding to hERG (IC50= 70 nM) and alpha1-adrenergic receptor (IC50= 4.9 ?M).
生化/生理作用
Reversible: yes
Primary Target
GluN2B NMDA Receptor
包装
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Yuan, H., et al. 2015.Neuron.85,1305.
Tahirovic, Y., et al. 2008.J. Med. Chem.51,5506.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C22H30Cl2N2O4S |
| 分子量 | 489.46 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | solid (sticky) |
| 效能 | 0.19 μM IC50 |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze protect from light |
| 颜色 | light yellow to yellow |
| 溶解性 | DMSO: 100 mg/mL |
| 储存温度 | ?20℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
