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位置: 首页> 品牌> Sigma-Aldrich> Dihydroorotate Dehydrogenase Inhibitor, Brequinar-CAS 96201-88-6-Calbiochem

Dihydroorotate Dehydrogenase Inhibitor, Brequinar-CAS 96201-88-6-Calbiochem

品牌
Sigma-Aldrich
CAS
96201-88-6
货号
5.08321
规格纯度
An immunosuppressive and anti-neoplastic agent that inhibits pyrimidine synthesis by blocking the activity of mammalian mitochondrial dihydroorotate dehydrogenase (DHODH; IC50= 12 nM).
价格
2408.9 *本价格含增值税费
促销
服务
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  • 增值税票
数量
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半岛bd体育手机客户端 名称:
96201-88-6
Dihydroorotate Dehydrogenase Inhibitor, Brequinar-CAS 96201-88-6-Calbiochem
NSC 368390, DuP 785, 6-fluoro-2-(2'-fluoro-1,1'-biphenyl-4-yl)-3-methyl-4-quinoline-carboxylic acid sodium salt
6-fluoro-2-(2'-fluoro-1,1'-biphenyl-4-yl)-3-methyl-4-quinoline-carboxylic acid sodium salt, NSC 368390, DuP 785
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A quinolinecarboxylic acid derivative with immunosuppressive and anti-neoplastic properties. Inhibits pyrimidine synthesis by blocking the activity of mammalian mitochondrial dihydroorotate dehydrogenase (DHODH; IC50= 12 nM). Does not affect DHODH in non-mammalian species. Also reported to inhibit glycosylation of adhesion molecules. Potentiates the sensitivity of U1690 small cell lung cancer cells to TRAIL-induced apoptosis and synergistically enhances the anti-tumor effects of doxorubicin ( ~100 ?M).

生化/生理作用

Cell permeable: yes
Primary Target
DHODH

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

He, T. et al. 2013.Oncogene32,in press.
Hurt, D.E., et al. 2006.Bioorg. Med. Chem. Lett.16,1610.
Schnellrath, L. et al. 2011.Int. J. Antimicrob. Agents.38,435.
Batt, D.G., et al. 1995.Bioorg. Med. Chem. Lett.14,1549.
Allison, A., et al. 1993.Transplantation Proc.25,67.
Cramer, D. et al. 1992.Transplantation.53,303.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C23H14F2NNaO2
分子量 397.35

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 solid
效能 12 nM IC50
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
protect from light
颜色 off-white
溶解性 DMSO: 50 mg/mL
储存温度 2-8℃
InChI 1S/C23H15F2NO2.Na/c1-13-21(23(27)28)18-12-16(24)10-11-20(18)26-22(13)15-8-6-14(7-9-15)17-4-2-3-5-19(17)25;/h2-12H,1H3,(H,27,28);/q;+1/p-1
InChI key PZOHOALJQOFNTB-UHFFFAOYSA-M

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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