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Benztropine-CAS 132-17-2-Calbiochem

品牌
Sigma-Aldrich
CAS
132-17-2
货号
5.09890
规格纯度
An antagonist of muscarinic M1 and M3 receptors that induces robust differentiation of oligodendrocytes precursor cell differentiation (EC50= 500 nM) and promotes myelination.
价格
1003.88 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
132-17-2
Benztropine-CAS 132-17-2-Calbiochem
Benzatropine, Cogentin
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A brain penetrating azabicyclo[3.2.1]octane derivative with anti-cholinergic and anti-histaminergic properties. Acts as an antagonist of muscarinic M1 and M3 receptors induces robust differentiation of oligodendrocytes precursor cell differentiation (OPC; EC50= 500 nM) and promotes myelination. Reduces the expression of Notch 1 in immature OPC and reduces the levels of cyclin D1 and D2 and c-Fos and c-Jun indicating its inhibitory effect on cell cycle progression. Shown to reduce the severity of the acute phase of multiple sclerosis and virtually eliminates the relapse phase in animal models. Significantly reduces the severity in the experimental autoimmune encephalomyelitis (EAE) model of relapsing-remitting multiple sclerosis when administered alone or co-administered with FTY720 (Cat. No. 344597).

生化/生理作用

Cell permeable: yes
Reversible: yes
Primary Target
Muscarinic M1/M3

包装

Packaged under inert gas

警告

Toxicity: Toxic (F)

其他说明

Deshmukh, V.A, et al. 2013.Nature502,327.
Doshay, L.J., et al. 1956.J Am Med Assoc.162,1031.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C21H2NO · xCH4O3S
分子量 284.25 (free base basis)
MDL编号 MFCD00074784

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 solid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
protect from light
颜色 white
储存温度 2-8℃
InChI 1S/C21H25NO.CH4O3S/c1-22-18-12-13-19(22)15-20(14-18)23-21(16-8-4-2-5-9-16)17-10-6-3-7-11-17;1-5(2,3)4/h2-11,18-21H,12-15H2,1H3;1H3,(H,2,3,4)/t18-,19-;/m1./s1
InChI key CPFJLLXFNPCTDW-STYNFMPRSA-N

安全信息

象形图 GHS06
警示用语: Danger
危险声明 H302 - H311 + H331
预防措施声明 P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P311
危险分类 Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 4 Oral
储存分类代码 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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