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位置: 首页> 品牌> Sigma-Aldrich> AMP Deaminase Inhibitor, Cpd3-Calbiochem

AMP Deaminase Inhibitor, Cpd3-Calbiochem

品牌
Sigma-Aldrich
货号
5.33642
包装型号
规格纯度
价格
2995.48 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
AMP Deaminase Inhibitor, Cpd3-Calbiochem
(S)-6-(4-(((1-(isoquinolin-8-yl)ethyl)amino)methyl)phenyl)nicotinic acid , AMPD Inhibitor, Cpd3 , AMPD Inhibitor, AMP Deaminase Inhibitor
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A cell-permeable isoquinoline derivative that acts as a specific AMP competitive inhibitor of AMP deaminase (IC50= 38, 27, and 24 nM for human, rat, and mice, respectively). Potentiates low frequency electrical stimulation induced increase in AMP level, AMP:ATP ratio, and phosphorylation of AMPK (at Thr172), and acetyl-CoA carboxylase (at Ser218) in contracting rat epitrochlearis muscle. However, it does not affect basal AMPK activity and contraction-stimulated glucose uptake. Preincubation with this compound reduces basal IMP levels, but does affect the contraction-induced increases in IMP, adenosine, and inosine in any appreciable manner.

生化/生理作用

Cell permeable: yes

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Admyre, T., et al. 2014.Chem. Biol.21,1486.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C24H21N3O2
分子量 383.44

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 solid
效能 38 nM IC50
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
protect from light
颜色 white
溶解性 DMSO: 50 mg/mL
储存温度 2-8℃

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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