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Monoclonal Anti-WAS antibody produced in mouse

品牌
Sigma-Aldrich
货号
WH0007454M5
规格纯度
clone 3H5, purified immunoglobulin, buffered aqueous solution
价格
4474.51 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
Monoclonal Anti-WAS antibody produced in mouse
Anti-Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
Anti-WASP
Anti-IMD2
Anti-THC
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5′ UTR sequence, has been described, however, its full-length nature is not known. (provided by RefSeq)

免疫原

WAS (NP_000368, 57 a.a. ~ 170 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
LPPGAEHWTKEHCGAVCFVKDNPQKSYFIRLYGLQAGRLLWEQELYSQLVYSTPTPFFHTFAGDDCQAGLNFADEDEAQAFRALVQEKIQKRNQRQSGDRRQLPPPPTPANEER

外形

Solution in phosphate buffered saline, pH 7.4

法律信息

GenBank is a registered trademark of United States Department of Health and Human Services

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
偶联物 unconjugated
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 3H5, monoclonal
形式 buffered aqueous solution
species reactivity human
technique(s) indirect ELISA: suitable
western blot: 1-5 μg/mL
同位素/亚型 IgG2bκ
GenBank?accession no. NM_000377
UniProt登记号 P42768
运输 dry ice
储存温度 ?20℃
Gene Information human ... WAS(7454)

安全信息

储存分类代码 12 - Non Combustible Liquids
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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