Monoclonal Anti-BRCC2 antibody produced in mouse

半岛bd体育手机客户端 说明

一般描述

This gene encodes a BH3-like motif containing protein involved in cell death. The encoded protein may induce apoptosis in a caspase-dependent manner. The protein is localized in both the cytoplasm and the mitochondrion. [SH

免疫原

BRCC2 (NP_001001786, 2 a.a. ~ 108 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
VTLLPIEGQEVHFFEILESECVLYTGWIERASGSSIYPEAKARLPLEALLGSNKEPMLPKETVLSLKRYNLGSSAMKRNVPGHVLQRPSYLTRIQVTLLCNSSAEAL

生化/生理作用

BRCC2 or BH3-like motif containing, cell death inducer acts as a tumor suppressor by modulating the AKT8 virus oncogene cellular homolog (Akt) pathway in breast cancer tissue. It associates with Bcl-2 long isoform (BCL-XL). BRCC2 also stimulates the caspase-dependent mitochondrial cell death pathway.

特点和优势

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外形

Solution in phosphate buffered saline, pH 7.4

法律信息

GenBank is a registered trademark of United States Department of Health and Human Services

基本信息

MDL编号

MFCD01321778

半岛bd体育手机客户端 性质

质量水平	100
生物来源	mouse
偶联物	unconjugated
抗体形式	purified immunoglobulin
antibody product type	primary antibodies
克隆	3F4, monoclonal
形式	buffered aqueous solution
species reactivity	human
technique(s)	immunofluorescence: suitable indirect ELISA: suitable western blot: 1-5 μg/mL
同位素/亚型	IgG2aκ
GenBank?accession no.	NM_001001786
UniProt登记号	Q8IZY5
运输	dry ice
储存温度	?20℃
Gene Information	human ... BLID(414899)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	nwg
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)