半岛bd体育手机客户端 说明
一般描述
A cell-permeable benzoimidazole derivative that acts as an inhibitor of repressor element-1 silencing transcription factor (REST, a Kruppel-type zinc finger transcription factor). Induces a dose-dependent reduction in the 122 kDa isoforms of REST in HEK cells. It is believed to target REST degradation, but not its expression or binding to repressor element binding sequence. Shown to rescue REST-regulated gene expressions, such as BDNF in the prefrontal cortex in mice with quinolinic acid-induced striatal lesions. Acute ventricular delivery of X5050 increases the expression of BDNFand other REST-regulated genes. Also shown to promote the expression of BDNF and SNAP25 in human neural stem cells via degradation of REST.
A cell-permeable benzoimidazole derivative that acts as an inhibitor of repressor element-1 silencing transcription factor (REST, a Kruppel-type zinc finger transcription factor). Induces a dose-dependent reduction in the 122 kDa isoforms of REST in HEK cells. It is believed to target REST degradation, but not its expression or binding to repressor element binding sequence. Shown to rescue REST-regulated gene expressions, such as BDNF in the prefrontal cortex in mice with quinolinic acid-induced striatal lesions. Acute ventricular delivery of X5050 increases the expression of BDNFand other REST-regulated genes. Also shown to promote the expression of BDNF and SNAP25 in human neural stem cells via degradation of REST.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
生化/生理作用
Cell permeable: yes
Primary Target
REST
包装
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Charbord, J., et al, 2013,Stem Cells31,1816.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
经验(实验)分子式 | C17H15N3O3 |
分子量 | 309.32 |
半岛bd体育手机客户端 性质
质量水平 | 100 |
测定 | ≥97% (HPLC) |
形式 | powder |
manufacturer/tradename | Calbiochem? |
储存条件 | OK to freeze protect from light |
颜色 | light beige |
溶解性 | DMSO: 100 mg/mL |
储存温度 | 2-8℃ |
安全信息
储存分类代码 | 11 - Combustible Solids |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich