半岛bd体育手机客户端 说明
一般描述
A 2′,3′-dialdehyde derivative of ATP that is commonly used to affinity label nucleotide sites in enzymes. Acts as a specific, irreversible antagonist of P2Z/P2X7purinergic receptors in J774 mouse macrophages. Does not affect P2γreceptors. Inhibits inflammatory pain in arthritic rat model by blocking ATP action on P2X7receptor in nerve terminals. Also shown to irreversibly block ATP-induced Ca2+influx in lymphocytes (?100 ?M). O-ATP-treated mice display better preservation and lower rate of rejection of pancreatic islet grafts with reduced Th1 transcripts.
生化/生理作用
Reversible: no
警告
Toxicity: Standard Handling (A)
其他说明
Vergani, A., et al. 2013.Diabetes62,1665.
Dell?Antonio, G., et al. 2002.Arthritis Rheum.46,3378.
Wiley, J.S., et al. 1994.Br. J. Pharmacol.112,946.
Murgia, M., et al. 1992.J. Biol. Chem.268,8199.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C10H14N5O13P3 |
| 分子量 | 505.17 |
| MDL编号 | MFCD00056956 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥97% (HPLC) |
| 形式 | powder |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze protect from light |
| 颜色 | white |
| 溶解性 | water: 50 mg/mL |
| 储存温度 | ?20℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
