Brk Inhibitor, Cpd 4f-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A cell permeable pyridoindole based compound that acts as a highly potent and selective inhibitor of breast tumor kinase (Brk; IC₅₀= 3.15 nM) with minimal or no effect against a panel of more than 30 other protein kinases (IC₅₀= <10 ?M for PIM2, NEK1 and2, CAMK4, MAPKAPK3 and 5 and MARK1, 3, and 5). Does not affect the activity of Akt isoforms, AGC kinases, ERK1 and 2, JNK 1 and 2 and HIPK isoforms. Displays anti-proliferative activity against multiple breast cancer cell lines (GI₅₀= 990 nM; 1.02 ?M, and 1.58 ?M for MCF7, HS-578/T, BT-549, respectively).

Please note that the molecular weight for this compound is batch-specific due to variable water content.
A cell permeable pyridoindole based compound that acts as a highly potent and selective inhibitor of breast tumor kinase (Brk; IC₅₀= 3.15 nM) with minimal or no effect against a panel of more than 30 other protein kinases (IC₅₀= <10 ?M for PIM2, NEK1 and2, CAMK4, MAPKAPK3 and 5 and MARK1, 3, and 5). Does not affect the activity of Akt isoforms, AGC kinases, ERK1 and 2, JNK 1 and 2 and HIPK isoforms. Displays anti-proliferative activity against multiple breast cancer cell lines (GI₅₀= 990 nM; 1.02 ?M, and 1.58 ?M for MCF7, HS-578/T, BT-549, respectively).

生化/生理作用

Cell permeable: yes
Primary Target
Brk

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Use only fresh DMSO for reconstitution.
Following reconstitution, aliquot and freeze (-70°C). Stock solutions are good for up to 2 weeks at -70°C.

其他说明

Mahmoud, K. A., et al. 2014.Bioorg. Med. Chem. Lett.24,1948.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C17H13N3O
分子量	275.30

半岛bd体育手机客户端 性质

质量水平	100
测定	≥97% (HPLC)
形式	powder
效能	3.15 nM IC50
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze protect from light
颜色	light beige
溶解性	DMSO: 100 mg/mL
储存温度	?20℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable