PKR/PERK Activator, DHBDC-Calbiochem

品牌

Sigma-Aldrich

货号

5.31551

包装型号

10 mg, A cell permeable dual activator of protein kinase R (PKR) and protein kinase R like kinase (PERK). Induces the phosphorylation of IκBα and thereby activates NF-κB pathway.

规格纯度

A cell permeable dual activator of protein kinase R (PKR) and protein kinase R like kinase (PERK). Induces the phosphorylation of IκBα and thereby activates NF-κB pathway.

价格

2620.01 元 *本价格含增值税费

促销

数量

- +

半岛bd体育手机客户端名称：

PKR/PERK Activator, DHBDC-Calbiochem
Protein Kinase R (PKR) Activator, Protein Kinase R Like Kinase (PERK) Activator

半岛bd体育手机客户端介绍：

半岛bd体育手机客户端说明

一般描述

A cell permeable chromenone derivative that acts as a dual activator of protein kinase R (PKR) and protein kinase R like kinase (PERK). Induces the phosphorylation of IkBa and thereby activates NF-κB pathway. However, the activation of NF-κB is independent of PKR activity. Induces elF2a phosphorylation and activates its downstream effectors CHOP/GADD153. Does not affect the phosphorylation of Akt, MAP kinase, or 4E-BP1. Inhibits the expression of cyclin D1 and E and blocks the growth of CRL-2813 and MCF-7 cells (IC₅₀= ~ 10 ?M). Also shown to reduce JFH1 hepatitis C virus infectivity (~40% inhibition at 5 ?M).
A cell permeable chromenone derivative that acts as a dual activator of protein kinase R (PKR) and protein kinase R like kinase (PERK). Induces the phosphorylation of IkBa and thereby activates NF-κB pathway. However, the activation of NF-κB is independent of PKR activity. Induces elF2a phosphorylation and activates its downstream effectors CHOP/GADD153. Does not affect the phosphorylation of Akt, MAP kinase, or 4E-BP1. Inhibits the expression of cyclin D1 and E and blocks the growth of CRL-2813 and MCF-7 cells (IC₅₀= ~ 10 ?M). Also shown to reduce JFH1 hepatitis C virus infectivity (~40% inhibition at 5 ?M).

Please note that the molecular weight for this compound is batch-specific due to variable water content.

生化/生理作用

Cell permeable: yes
Primary Target
PKR and PERK

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Bai, H., et al. 2013.ChemBioChem14,1255.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₁₇H₁₂O₆
分子量	312.27

半岛bd体育手机客户端性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
效能	~10 μM IC₅₀
manufacturer/tradename	Calbiochem^?
储存条件	OK to freeze protect from light
颜色	pink
溶解性	DMSO: 100 mg/mL
储存温度	?20℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable