L- Buthionine Sulfoximine-CAS 83730-53-4-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A cell-permeable, sulfoximine based compound that acts a potent, fast acting, irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. Closely resembles the structure of g-glutamylphosphate cysteine adduct. The inhibition follows the first order kinetics with t1/2 = ~ 11 sec at saturating inhibitor concentration. Does not affect the activity of glutamine synthetase. Shown to improve the outcome of chemotherapy by lowering the levels of glutathione in cancer cells (IC₅₀= 1.9, 8.6, and 29 ?M in melanoma, breast, and ovarian tumor cells, respectively).
A cell-permeable, sulfoximine based compound that acts a potent, fast acting, irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. Closely resembles the structure of g-glutamylphosphate cysteine adduct. The inhibition follows the first order kinetics with t_1/2= ~ 11 sec at saturating inhibitor concentration. Does not affect the activity of glutamine synthetase. Shown to improve the outcome of chemotherapy by lowering the levels of glutathione in cancer cells (IC₅₀= 1.9, 8.6, and 29 ?M in melanoma, breast, and ovarian tumor cells, respectively).

生化/生理作用

Primary Target
gamma-glutamylcysteine synthetase

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Fruehauf, J.P., et al. 1997.Pigment Cell Res.10,236.
O?Dwyer, P.J., et al. 1996.J. Clin. Oncol.14,249.
Griffith, O. W., 1982.J. Biol. Chem.257,13704.

Griffith, O. W., et al. 1979.J. Biol. Chem.254,7558.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C8H18N2O3S
分子量	222.31
MDL编号	MFCD00067000

半岛bd体育手机客户端 性质

质量水平	100
测定	≥97% (TLC)
形式	powder
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze protect from light
颜色	white
溶解性	water: 50 mg/mL
储存温度	2-8℃
InChI	1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)/t7-,14?/m0/s1
InChI key	KJQFBVYMGADDTQ-CVSPRKDYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable