InSolution Phorbol-12-myristate-13-acetate-CAS 16561-29-8-Calbiochem

半岛bd体育手机客户端 说明

一般描述

Most commonly-used phorbol ester. Extremely potent mouse skin tumor promoter. Activates protein kinase Cin vivoandin vitro, even at nM concentrations. Promotes the expression of iNOS in cultured hepatocytes. Activates Ca²⁺-ATPase and potentiates forskolin (>Cat. No. 344270, >Cat. No. 344282)-induced cAMP formation. Inhibits apoptosis induced by the Fas antigen, but induces apoptosis in HL-60 promyelocytic leukemia cells. Its binding is reversible.

生化/生理作用

Cell permeable: yes
Secondary Target
Ca²⁺-ATPase
Reversible: yes
Primary Target
PKC

包装

Packaged under inert gas

警告

Toxicity: Irritant (B)

外形

A 10 mM (2 mg/324 ?L) solution of Phorbol-12-myristate-13-acetate (Cat. No. 524400) in DMSO.

重悬

Following initial thaw, aliquot and freeze (-70°C). Use only fresh DMSO for preparing further dilutions.

其他说明

Powell, D.J., et al. 2003.Mol. Cell Biol.23,7794.
Tepper, C.G., et al. 1995.Proc. Natl. Acad. Sci. USA92,8443.
Oishi, K., and Yamaguchi, M. 1994.J. Cell. Biochem.55,168.
Macfarlane, D.E., and O′Donnell, P.S. 1993.Leukemia7,1846.
Ghandi, V.C. and Jones, D.J., 1992.Neuropharmacol.31,1101.
Hortelano, S., et al. 1992.J. Biol. Chem.267,24937.
Kontny, E., et al. 1992.Eur. J. Pharmacol.227,333.
Zanaboni, P.B., et al. 1992.J. Appl. Physiol.73,2011.
Saltis, J., et al. 1991.J. Biol. Chem.266,261.
Beguinot, L., et al. 1985.Proc. Natl. Acad. Sci. USA82,2774.
Perchellet, J. 1985.Carcinogenesis6,567.
Nishizuka, Y. 1984.Science255,1365.
Mastro, A. 1982.Lymphokines6,263.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C36H56O8
分子量	616.83
MDL编号	MFCD00036736

半岛bd体育手机客户端 性质

质量水平	100
测定	≥98% (HPLC)
形式	liquid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze avoid repeated freeze/thaw cycles desiccated (hygroscopic) protect from light
储存温度	?70℃
InChI	1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,27+,28-,30-,32-,34-,35-,36-/m1/s1
InChI key	PHEDXBVPIONUQT-RGYGYFBISA-N

安全信息

象形图
警示用语：	Danger
危险声明	H311 + H331 - H315 - H317 - H319 - H334 - H351
预防措施声明	P201 - P280 - P302 + P352 + P312 - P304 + P340 + P311 - P305 + P351 + P338 - P308 + P313
危险分类	Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Carc. 2 - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1
储存分类代码	6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK	WGK 2
闪点(F)	188.6 °F - (Dimethylsulfoxide)
闪点(C)	87 ℃ - (Dimethylsulfoxide)