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位置: 首页> 品牌> Sigma-Aldrich> InSolution IKK Inhibitor VII-CAS 873225-46-8-Calbiochem

InSolution IKK Inhibitor VII-CAS 873225-46-8-Calbiochem

品牌
Sigma-Aldrich
CAS
873225-46-8
货号
5.05378
包装型号
规格纯度
价格
1073.27 *本价格含增值税费
促销
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半岛bd体育手机客户端 名称:
873225-46-8
InSolution IKK Inhibitor VII-CAS 873225-46-8-Calbiochem
IKK 16, (4-(4-(Benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)phenyl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone, InSolution IKK Inhibitor VII
(4-(4-(Benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)phenyl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone, InSolution IKK Inhibitor VII, IKK 16
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A cell-permeable benzamido-pyrimidine compound that acts as a potent, selective, and ATP-competitive inhibitor of IKK (IC50= 40, 70, and 200 nM for IKK-2, IKK complex, and IKK-1, respectively). Inhibits cellular IκBα degradation and NF-κB-mediated gene expression in vitro in HUVEC cells and has been shown to exhibit excellentin vivoefficacy both in mice and rats.

生化/生理作用

Cell permeable: yes
Reversible: yes
Primary Target
IKK-2, IKK complex, and IKK-1

包装

Packaged under inert gas

警告

Toxicity: Irritant (B)

外形

A 10 mM (500 ?g/103 ?L) sterile-filtered solution of IKK Inhibitor VII (Cat. No. 401486) in DMSO.

重悬

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.

其他说明

Waelchli, R., et al. 2006.Bioorg. Med. Chem. Lett.16,108.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C28H29N5OS
分子量 483.63

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥97% (HPLC)
形式 liquid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light
储存温度 ?70℃

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