InSolution Calyculin A,Discodermia calyx-CAS 101932-71-2-Calbiochem

半岛bd体育手机客户端 说明

一般描述

Cell-permeable protein phosphatase 2A (PP2A) inhibitor (IC₅₀= 0.5-1.0 nM). Also inhibits protein phosphatase 1 (PP1; IC₅₀= 2 nM). A non-phorbol ester type tumor promoter that induces oxidative DNA damage. Selectively increases the efficacy of AMPA receptor-mediated synaptic transmission at excitatory synapses. Recently, it has been used to study the regulation of Ca²⁺-activated K⁺channels in smooth muscle and to correlate shape changes in fibroblasts with the degree of protein phosphorylation. Also known to prevent γ-radiation induced apoptosis in Burkitt′s lymphoma cell line BM13674.

生化/生理作用

Cell permeable: yes
Target IC₅₀: 0.5-1.0 and 2 nM for PP2A and PP1, respectively
Reversible: yes
Primary Target
protein phosphatase-2A & -1

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

外形

A 100 ?M (5 ?g/50 ?L) sterile-filtered solution of Calyculin A,Discodermia calyx(Cat. No. 208851) in DMSO.

重悬

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C. Use only fresh DMSO for further dilutions.

其他说明

Murakami, N., et al. 1994.Neurosci. Lett.176,181.
Takeuchi, T., et al. 1994.Biochem. Biophys. Res. Commun.205,1803.
Figurov, A., et al. 1993.Eur. J. Neurosci.5,1083.
Song, Q., and Lavin, M.F. 1993.Biochem. Biophys. Res. Commun.190,47.
Gopalakrishna, R., et al. 1992.Biochem. Biophys. Res. Commun.189,950.
Carl, A., et al. 1991.Am. J. Physiol.261,C387.
Suganuma, M., et al. 1990.Cancer Res.50,3521.
Cohen, P. 1989.Annu. Rev. Biochem.58,453.
Cohen, P., et al. 1989.J. Biol. Chem.264,21435.
Ishihara, H., et al. 1989.Biochem. Biophys. Res. Commun.159,871.
Kato, Y., et al. 1988.J. Org. Chem.53,3930.
Kato, Y., et al. 1986.J. Am. Chem. Soc.108,2780.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C50H81N4O15P
分子量	1009.17
MDL编号	MFCD06795864

半岛bd体育手机客户端 性质

质量水平	100
测定	≥98% (HPLC)
形式	liquid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze avoid repeated freeze/thaw cycles desiccated (hygroscopic) protect from light
储存温度	?70℃
InChI	1S/C50H81N4O15P/c1-29(20-22-51)16-14-17-30(2)32(4)24-33(5)42(57)35(7)38(55)25-41(65-13)45-46(69-70(61,62)63)49(8,9)50(68-45)26-39(56)34(6)40(67-50)19-15-18-36-27-66-48(53-36)31(3)21-23-52-47(60)44(59)43(58)37(28-64-12)54(10)11/h14-18,20,24,27,31,33-35,37-46,55-59H,19,21,23,25-26,28H2,1-13H3,(H,52,60)(H2,61,62,63)/b16-14+,18-15+,29-20-,30-17+,32-24+/t31-,33+,34+,35+,37-,38-,39-,40+,41-,42+,43-,44-,45+,46-,50-/m0/s1
InChI key	FKAWLXNLHHIHLA-QJLNTFFJSA-N

安全信息

储存分类代码	10 - Combustible liquids
WGK	WGK 1
闪点(F)	188.6 °F - (refers to pure substance)
闪点(C)	87 ℃ - (refers to pure substance)