半岛bd体育手机客户端 说明
一般描述
A selective 5-HT7receptor antagonist. Extremely potentin vivoandin vitro. Chronic or acute (even single dose) administration of SB269970 induces functional desensitization of the 5-HT7receptor system, which precedes changes in the receptor density. This mechanism may be responsible for the rapid antidepressant-like effect of the 5-HT7antagonist in animal models. SB-269970 is an analogue of SB-258719 and has been shown to have at least 100 fold selectivity versus all other 5-HT receptor subtypes except the human 5-HT5Areceptor (pKi values are 8.9, 7.2 and 6.0 for 5-HT7A, 5-HT5Aand 5-HT1B).
生化/生理作用
Primary Target
5-HT?
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Tokarski, K. et al. 2012.Pharmacol. Rep.64,256.
Thomas. D. R. et al. 2000.Br. J. Pharmacol.130,409.
Lovell, P. J. et al. 2000.J. Med. Chem.43,342.
Forbes, I. T. et al. 1998.J. Med. Chem.41,655.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C18H28N2O3S · xHCl |
| 分子量 | 352.49 (free base basis) |
| MDL编号 | MFCD03788020 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze protect from light |
| 颜色 | off-white |
| 溶解性 | DMSO: soluble |
| 储存温度 | 2-8℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
