半岛bd体育手机客户端 说明
一般描述
A selective, brain-penetrant 5-HT2Creceptor antagonist (pKi 8.2-9.0 ), with some effects on the 5-HT2Breceptor (pKi 6.8-7.0) and 5-HT2Areceptor (pKi 6.1-6.8). SB 242084 has been shown to increase the effectiveness of the selective serotonin reuptake inhibitor (SSRI) class of antidepressants, and may also reduce their side effects. In animal studies, SB-242,084 produced stimulant-type activity and reinforcing effects, somewhat similar to but much weaker than cocaine or amphetamines.In vivo(ocular) IC50values reported at 2.08 ?M.
生化/生理作用
Primary Target
5-HT2C
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Manvich, D. F., et al. 2012.J Pharmacol. Exp. Ther.342,761.
Burghardt, N. S., et al. 2007.Biol Psychiatry62,1111.
Sharif, N. A., et al. 2007.J. Ocul. Pharmacol. Ther.23,1.
Knight A. R., et al. 2004.Naunyn Schmiedebergs Arch. Pharmacol.370,114.
Kennett G.A., et al. 1997.Neuropharmacol.36,609.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C21H19ClN4O2· xHCl |
| 分子量 | 394.85 (free base basis) |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze protect from light |
| 颜色 | off-white to pale yellow pale yellow |
| 溶解性 | water: soluble |
| 储存温度 | ?20℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
