半岛bd体育手机客户端 说明
一般描述
A cell-permeable, selenium-to-sulfur substituted Ebselen (Cat. No. 324483) derivative that exhibits similar NOX2 inhibitory activity as Ebselen by blocking p22phoxc-terminal PRD (proline-rich domain) and p47phoxbis-SH3 interaction. Although less potent than Ebselen in cell-free p22phoxPRD-p47phoxbis-SH3 binding (IC50= 4 vs. 0.3 ?M) and NOX2 activity (IC50= 4 vs. 0.6 ?M) assays, Thr101 is more potent and NOX2-selective than Ebselen in cell-based assays (Thr101 IC50/Ebselen IC50= 0.3/0.5, 3/0.15, 8/no inhibition, 8/0.7 ?M, respectively, against NOX2, NOX1, NOX4, and NOX5) and exhibits no glutathione peroxidase activity.
A cell-permeable, selenium-to-sulfur substituted Ebselen (Cat. No. 324483) derivative that exhibits similar NOX2 inhibitory activity as Ebselen by blocking p22phoxc-terminal PRD (proline-rich domain) and p47phoxbis-SH3 interaction. Although less potent than Ebselen in cell-free p22phoxPRD-p47phoxbis-SH3 binding (IC50= 4 vs. 0.3 ?M) and NOX2 activity (IC50= 4 vs. 0.6 ?M) assays, Thr101 is more potent and NOX2-selective than Ebselen in cell-based assays (Thr101 IC50/Ebselen IC50= 0.3/0.5, 3/0.15, 8/no inhibition, 8/0.7 ?M, respectively, against NOX2, NOX1, NOX4, and NOX5) and exhibits no glutathione peroxidase activity.
Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
生化/生理作用
Cell permeable: yes
Primary Target
blocks p22phoxc-terminal PRD (proline-rich domain) and p47phoxbis-SH3 interaction
包装
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Smith, S.M.E., et al. 2012.Chem. Biol.19,752.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
经验(实验)分子式 | C14H10FNOS |
分子量 | 259.30 |
半岛bd体育手机客户端 性质
质量水平 | 100 |
测定 | ≥98% (HPLC) |
形式 | powder |
manufacturer/tradename | Calbiochem? |
储存条件 | OK to freeze protect from light |
颜色 | light brown |
溶解性 | DMSO: 50 mg/mL |
储存温度 | 2-8℃ |
安全信息
储存分类代码 | 11 - Combustible Solids |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich