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位置: 首页> 品牌> Sigma-Aldrich> NOX Inhibitor VII, Thr101-Calbiochem

NOX Inhibitor VII, Thr101-Calbiochem

品牌
Sigma-Aldrich
货号
5.00526
包装型号
规格纯度
价格
3040.98 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
NOX Inhibitor VII, Thr101-Calbiochem
NADPH Oxidase Inhibitor VII, 6-Fluoro-2- o-tolylbenzo[d]isothiazol-3(2H)-one, 6-Fluoro-2-(2-methylphenyl)-1,2-benzothiazol-3(2H)-one
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A cell-permeable, selenium-to-sulfur substituted Ebselen (Cat. No. 324483) derivative that exhibits similar NOX2 inhibitory activity as Ebselen by blocking p22phoxc-terminal PRD (proline-rich domain) and p47phoxbis-SH3 interaction. Although less potent than Ebselen in cell-free p22phoxPRD-p47phoxbis-SH3 binding (IC50= 4 vs. 0.3 ?M) and NOX2 activity (IC50= 4 vs. 0.6 ?M) assays, Thr101 is more potent and NOX2-selective than Ebselen in cell-based assays (Thr101 IC50/Ebselen IC50= 0.3/0.5, 3/0.15, 8/no inhibition, 8/0.7 ?M, respectively, against NOX2, NOX1, NOX4, and NOX5) and exhibits no glutathione peroxidase activity.
A cell-permeable, selenium-to-sulfur substituted Ebselen (Cat. No. 324483) derivative that exhibits similar NOX2 inhibitory activity as Ebselen by blocking p22phoxc-terminal PRD (proline-rich domain) and p47phoxbis-SH3 interaction. Although less potent than Ebselen in cell-free p22phoxPRD-p47phoxbis-SH3 binding (IC50= 4 vs. 0.3 ?M) and NOX2 activity (IC50= 4 vs. 0.6 ?M) assays, Thr101 is more potent and NOX2-selective than Ebselen in cell-based assays (Thr101 IC50/Ebselen IC50= 0.3/0.5, 3/0.15, 8/no inhibition, 8/0.7 ?M, respectively, against NOX2, NOX1, NOX4, and NOX5) and exhibits no glutathione peroxidase activity.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

生化/生理作用

Cell permeable: yes
Primary Target
blocks p22phoxc-terminal PRD (proline-rich domain) and p47phoxbis-SH3 interaction

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Smith, S.M.E., et al. 2012.Chem. Biol.19,752.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C14H10FNOS
分子量 259.30

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 powder
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
protect from light
颜色 light brown
溶解性 DMSO: 50 mg/mL
储存温度 2-8℃

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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