您好,欢迎来到半岛电竞官方网址 ! [ 登录] [ 免费注册]
半岛电竞官方网址
位置: 首页> 品牌> Sigma-Aldrich> NMDA Antagonist XI, N1-dansyl-spermine-Calbiochem

NMDA Antagonist XI, N1-dansyl-spermine-Calbiochem

品牌
Sigma-Aldrich
货号
5.05764
包装型号
规格纯度
价格
2442.83 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
NMDA Antagonist XI, N1-dansyl-spermine-Calbiochem
NMDA channel blocker, N1-dansyl-spermine, N1-DnsSpm
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

An N-sulfonyl-polyamine that acts as a potent and more specific antagonist of NMDA receptors expressed in Xenopus oocytes (IC50= 310, 340 nM in NR1/NR2A and NR1/NR2B, respectively). The inhibition appears to be voltage-dependent and is non-competitive with respect to glutamate and glycine. Exhibits about 50-fold greater selectivity over NR1/NR2C and NR1/NR2D receptors (IC50= 16 and 13 ?M, respectively). Also shown to block c-AMP-dependent, calmodulin-activated phosphodiesterase (IC50= 58 ?M) and diminishes the induction of ornithine decarboxylase. At higher concentration (?100 ?M) it is shown to reduce spontaneous epileptiform activity in mouse cortical slices.

生化/生理作用

Primary Target
NMDA

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Kirby, B.P., et al. 2005,Eur. J. Pharmacol.524,53.
Li, J., et al. 2005,Brain Res.1055,180.
Kirby, B. et al. 2004,Brain Res.1011,69.
Seiler, N., et al. 1998,J. Biochem. Cell Biol.30,393.

Chao, J., et al. 1997,Mol. Pharm.51,861.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C22H37N5O2S · 3HCl
分子量 545.01

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥97% (HPLC)
形式 powder
效能 0.31 μM IC50
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
protect from light
颜色 yellow-white
溶解性 DMSO: 100 mg/mL
储存温度 2-8℃

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

推荐半岛bd体育手机客户端
Baidu
map