半岛bd体育手机客户端 说明
一般描述
Active hormonal form of vitamin D, formed by the renal 1-hydroxylation of 25-(OH)D3. Has immunomodulatory propertiesin vitroandin vivo. Prevents the development of clinical diabetes in NOD mice, which are an animal model of human autoimmune diabetes. Induces reversible hydrolysis of the sphingomyelin cycle and generates ceramide. Stimulates intestinal Ca2+and phosphate transport and mobilizes Ca2+from bone. Involved in cellular differentiation, carcinogenesis, and insulin secretion.
生化/生理作用
Primary Target
vitamin D receptor
包装
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
外形
A 1 mM (50 ug/112 ?L) solution of Vitamin D3, 1α, 25-Dihydroxy- (Cat. No. 679101) in DMSO.
重悬
Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
其他说明
Semizarov, D., et al. 1998.Proc. Natl. Acad. Sci. USA95,15412.
Hannun, Y.A. 1994.J. Biol. Chem.269,3125.
Mathieu, C., et al. 1994.Diabetologica37,552.
Thomasset, M. 1994.Pathol. Biol.42,163.
Horton, W.E., Jr., et al. 1991.J. Biol. Chem.266,24804.
Larsen, C.G., et al. 1991.Biochem. Biophys. Res. Commun.176,1020.
Thavarajah, M., et al. 1991.Biochem. Biophys. Res. Commun.176,1189.
Wakasugi, M., et al. 1991.Prostaglandins42,127.
Matsumoto, K., et al. 1990.Biochem. Biophys. Res. Commun.166,916.
Simpson, R.U., et al. 1989.J. Biol. Chem.264,19710.
DeLuca, H.F., and Schnoes, H.K. 1983.Annu. Rev. Biochem.52,411.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C27H44O3 |
| 分子量 | 416.64 |
半岛bd体育手机客户端 性质
| 测定 | ≥99% (HPLC) |
| 质量水平 | 200 |
| 形式 | liquid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze avoid repeated freeze/thaw cycles desiccated (hygroscopic) protect from light |
| 储存温度 | ?70℃ |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 1 |
| 闪点(F) | 188.6 °F - (refers to pure substance) |
| 闪点(C) | 87 ℃ - (refers to pure substance) |
Sigma-Aldrich
m.cnreagent.com
