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位置: 首页> 品牌> Sigma-Aldrich> Anti-Pancreatic Polypeptide Antibody, clone 3H5, ZooMAb?Rabbit Monoclonal

Anti-Pancreatic Polypeptide Antibody, clone 3H5, ZooMAb?Rabbit Monoclonal

品牌
Sigma-Aldrich
货号
ZRB939
规格纯度
recombinant, expressed in HEK 293 cells
价格
2138.93 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
Anti-Pancreatic Polypeptide Antibody, clone 3H5, ZooMAb ?Rabbit Monoclonal
Pancreatic Prohormone
PP
Obinepitide
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

ZooMAb antibodies represent an entirely new generation of recombinant monoclonal antibodies.

Each ZooMAb antibody is manufactured using our proprietary recombinant expression system, purified to homogeneity, and precisely dispensed to produce robust and highly reproducible lot-to-lot consistency. Only top-performing clones are released for use by researchers. Each antibody is validated for high specificity and affinity across multiple applications, including its most commonly used application. ZooMAb antibodies are reliably available and ready to ship when you need them.

Learn more about ZooMAb here.

特异性

Clone 3H5 is a ZooMAb rabbit recombinant monoclonal antibody that specifically detects human Pancreatic Polypeptide.

免疫原

KLH-conjugated linear peptide corresponding to full-length human Pancreatic Polypeptide (without the signal and propeptides).

应用

Anti-Pancreatic Polypeptide, clone 3H5 ZooMAb, Cat. No. ZRB939, is a recombinant Rabbit Monoclonal Antibody that detects pancreatic polypeptide and has been tested for use in Immunocytochemistry, Immunohistochemistry (Paraffin), Immunofluorescence, and Western Blotting.
Immunofluorescence Analysis: A 1:400 dilution from a representative lot detected Pancreatic Polypeptide in human pancreas tissue sections.
Immunohistochemistry (Paraffin) Analysis: A 1:400 dilution from a representative lot detected Pancreatic Polypeptide in human pancreas tissue sections.
Immunocytochemistry Analysis: A 1:100 dilution from a representative lot detected Pancreatic Polypeptide in TGP52 cell line.

目标描述

Pancreatic polypeptide (UniProt: P01298; also known as PP, Obinepitide, Pancreatic prohormone) is encoded by the PPY (also known as PNP) gene (Gene ID: 5539) in human. Pancreatic polypeptide is a member of the neuropeptide Y family and is secreted protein that is produced by PP cells in the pancreatic islets of Langerhans. The pancreatic prohormone is synthesized with a signal peptide (aa 1-29) and a propeptide (aa 89-95) that are subsequently cleaved off. The remaining part is cleaved off into pancreatic hormone (aa 30-65) and pancreatic icosapeptide (69-88). Pancreatic hormone acts as a regulator of pancreatic and gastrointestinal functions. Two isoforms of pancreatic polypeptide have been described that are generated by alternative splicing. Pancreatic polypeptide release is functionally associated with increased satiety, delayed gastric emptying, inhibition of gallbladder motility, and regulation of energy expenditure. Its deficiency is observed in cases of pancreatic resection and chronic pancreatitis and is associated with significant reduction in PP cell mass and abnormally high hepatic glucose production even in the presence of endogenous insulin. This ZooMAb recombinant monoclonal antibody, generated by our propriety technology, offers significantly enhanced specificity, affinity, reproducibility, and stability over conventional monoclonals. (Ref.: Maxwell, J et al. (2014). Pancreas 43(4); 651-656).

外形

Purified recombinant rabbit monoclonal antibody IgG, lyophilized in PBS with 5% Trehalose, normal appearance a coarse or translucent resin. Contains no biocide or preservatives, such as azide, or any animal by-products. Larger pack sizes provided as multiples of 25 μL.

重悬

120 μg/mL after reconstitution at 25 μL. Please refer to guidance on suggested starting dilutions and/or titers per application and sample type.

储存及稳定性

Recommend storage of lyophilized product at 2-8℃; Before reconstitution, micro-centrifuge vials briefly to spin down material to bottom of the vial; Reconstitute each vial by adding 25 μL of filtered lab grade water or PBS; Reconstituted antibodies can be stored at 2-8℃, or -20℃ for long term storage. Avoid repeated freeze-thaws.

法律信息

ZooMAb is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

半岛bd体育手机客户端 性质

生物来源 rabbit (recombinant)
重组 expressed in HEK 293 cells
偶联物 unconjugated
抗体形式 purified antibody
antibody product type primary antibodies
克隆 3H5, monoclonal
recombinant monoclonal
半岛bd体育手机客户端 线 ZooMAb?learn more
形式 lyophilized
分子量 calculated mol wt 10.44 kDa
species reactivity human
species reactivity (predicted by homology) bovine
包装 antibody small pack of 25 μL
环保替代半岛bd体育手机客户端 特性 Waste Prevention
Designing Safer Chemicals
Design for Energy Efficiency
Learn more about thePrinciples of Green Chemistry.
增强验证 recombinant expression
Learn more aboutAntibody Enhanced Validation
technique(s) immunocytochemistry: suitable using 1:100
immunofluorescence: 1:100-1:400
immunofluorescence: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:400
western blot: suitable using 1:1,000
同位素/亚型 IgG
UniProt登记号 P01298
环保替代半岛bd体育手机客户端 分类 Aligned
运输 ambient
储存温度 2-8℃
Gene Information human ... PPY;PNP(5539)

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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