Anti-TLS Antibody, clone 1FU-1D2

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一般描述

The TLS/FUS protein contains an RNA-recognition motif and is a component of nuclear riboprotein complexes. It resembles a transcription factor in that it binds DNA, contributes a transcriptional activation domain to the FUS-ERG oncoprotein, and interacts with several transcription factors in vitro. It binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. It may play a role in maintenance of genomic integrity.

特异性

This antibody recognizes TLS.

免疫原

Linear peptide corresponding to human TLS.
Epitope: Unknown

应用

Research Sub Category
RNA Metabolism & Binding Proteins

Transcription Factors
Use Anti-TLS Antibody, clone 1FU-1D2 (Mouse Monoclonal Antibody) validated in WB, ICC to detect TLS also known as 75 kDa DNA-pairing protein, FUS-CHOP fusion protein.
Immunocytochemistry Analysis:
1:500 dilution from a representative lot detected TLS in C2C12 cells.
Research Category
Epigenetics & Nuclear Function

Epigenetics & Nuclear Function

质量

Evaluated by Western Blot in HepG2 cell lysate.
Western Blot Analysis: 1:1,000 dilution of this antibody detected TLS on 10 ?g of HepG2 cell lysate.

目标描述

Observed at 65 kDa

外形

Unpurified
Unpurified mouse monoclonal IgG1κ preservative-free ascites.

储存及稳定性

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

分析说明

Control
HepG2 cell lysate

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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