Anti-Lyn Antibody, clone 10A6.2

半岛bd体育手机客户端 说明

一般描述

Lyn (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) is a member of the Src family of protein tyrosine kinases and is expressed primarily in hematopoietic cells and neural tissues. Lyn is involved in the regulation of cell activation by undergoing phosphorylation upon activation. Lyn activation triggers downstream signaling pathways that are mediated by Lyn phosphorylation of tyrosine residues of receptor proteins and recruitment and activation of other kinases including Syk, phospholipase Cγ2 (PLCγ2) and phosphatidyl inositol-3 kinase. Lyn also plays an important role in B cells as a key regulator of both positive and negative signals, thus acting to maintain the balance between activation and inhibition. Deregulation of this balance can result in severe pathological consequences such as autoimmune disease.

特异性

Recognizes the C-terminus of Lyn (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog).

免疫原

KLH conjugated linear peptide corresponding to the C-terminus of Lyn.

应用

Western Blot Analysis: 1:500-1:1000 dilution of this lot detected Lyn in A431 cell lysate.
Anti-Lyn Antibody, clone 10A6.2 is an antibody against Lyn for use in WB.

质量

Routinely evaluated by western blot on A431 cell lysate.

目标描述

58 kDa

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

质量水平	100
生物来源	mouse
抗体形式	ascites fluid
antibody product type	primary antibodies
克隆	10A6.2, monoclonal
species reactivity	human
species reactivity (predicted by homology)	mouse (based on 100% sequence homology), chicken (based on 100% sequence homology), rat (based on 100% sequence homology)
manufacturer/tradename	Upstate?
technique(s)	western blot: suitable
同位素/亚型	IgG1κ
NCBI登记号	NP_001104567
UniProt登记号	Q6NUK7
运输	dry ice

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	nwg
闪点(F)	Not applicable
闪点(C)	Not applicable