Anti-phospho-SMC1 (Ser957) Antibody, clone 5D11G5 Alexa Fluor^?488

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一般描述

SMC (structural maintenance of chromosomes) proteins are Involved in chromosome cohesion during cell cycle and in DNA repair. ATM phosphorylates SMC1 on Ser957 and Ser966 both in vitro and in vivo. Phosphorylated SMC1 is part of the complex that functions as a downstream effector in both the ATM/NBS1 branch and the ATR/MSH2 branch of S-phase checkpoint.

特异性

Predicted to cross-react with xenopus and bovine based on sequence homology
Antibody recognizes SMC1 phosphorylolated at Ser957.

免疫原

Epitope: Phosphorylated at and around Ser957
KLH-conjugated, synthetic peptide corresponding to human SMC1 phosphorylated at Ser957

应用

Research Sub Category
Cell Cycle, DNA Replication & Repair
This Anti-phospho-SMC1 (Ser957) Antibody, clone 5D11G5 Alexa Fluor 488 is validated for use in WB, FC for the detection of phospho-SMC1 (Ser957).
Research Category
Epigenetics & Nuclear Function

Apoptosis & Cancer

质量

Evaluated by Flow Cytometry with Hela Cells

目标描述

150kDa Calculated

外形

Purified mouse monoclonal IgG1 conjugated to Alexa Flour 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA.
Protein G Purified

储存及稳定性

Maintain refrigerated at 2-8°C in undiluted aliquots for up to 6 months from date of receipt. Protect from light.

分析说明

Control
HeLa Cells

法律信息

ALEXA FLUOR is a registered trademark of Life Technologies

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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