Anti-Alzheimer Precursor Protein A4 Antibody, clone 22C11, Alexa488 Conj.

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Anti-Alzheimer Precursor Protein A4 Antibody, clone 22C11, Alexa488 Conj.
Amyloid beta A4 protein, ABPP, APPI, APP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, CVAP, PreA4, Protease nexin-II, PN-II, N-APP, Soluble APP-alpha, S-APP-alpha, Soluble APP-beta, S-APP-beta, C99, Beta-amyloid protein 42, Beta

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半岛bd体育手机客户端说明

一般描述

Deposits of amyloid protein in senile plaques near nerve processes are found in the brains of aged human and cases of Alzheimer′s Disease. The principle component of this extracellular amyloid is beta A4, a 4 kDa peptide derived from a larger amyloid precursor protein (APP), which is widely expressed in the brain and body. The creation, transport and function of these proteins is currently an active area of research.

特异性

Unconjugated MAB348 recognizes N-terminal amino acids 66-81 on the pre-A4 molecule (Hilbich et al., 1993). 22C11 recognizes all three isoforms of APP: immature, ~110kDa; sAPP, ~120kDa; and mature, ~130kDa (Hoffmann et al., 2000). This antibody is known to cross react with APLP2 (Slunt, 1994).

免疫原

Epitope: a.a. 66-81 of APP (N-terminus)

应用

Immunohistochmeistry Analysis: A 1:50 dilution from a representative lot detected Alzheimer Precursor Protein A4 in adult mouse brain tissue.
Anti-Alzheimer Precursor Protein A4 Antibody, clone 22C11, Alexa488 Conj. is an antibody against Alzheimer Precursor Protein A4 for use in IHC, ICC.

质量

Evaluated by Immunocytochemistry in mouse N1E-115 neuroblastoma cells.
Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected Alzheimer Precursor Protein A4 in mouse N1E-115 neuroblastoma cells.

目标描述

Reacts with pre-A4. The unconjugated antibody (MAB348) recognizes all three isoforms of APP, immature ~110kDa, sAPP ~120kDa, and mature ~130kDa (Hoffmann et al., 2000).

外形

Protein A purified

分析说明

Control
Mouse N1E-115 neuroblastoma cells

法律信息

ALEXA FLUOR is a registered trademark of Life Technologies

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端性质

质量水平	100
生物来源	mouse
偶联物	ALEXA FLUOR^?488
抗体形式	purified immunoglobulin
antibody product type	primary antibodies
克隆	22C11, monoclonal
species reactivity	pig, rat
species reactivity (predicted by homology)	monkey (based on 100% sequence homology), mouse (based on 100% sequence homology), porcine (based on 100% sequence homology), canine (based on 100% sequence homology), human (based on 100% sequence homology)
technique(s)	immunocytochemistry: suitable immunohistochemistry: suitable
同位素/亚型	IgG1
NCBI登记号	NP_000475
UniProt登记号	P05067
运输	wet ice
Gene Information	human ... APP(351)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable