半岛bd体育手机客户端 说明

一般描述

6-(5H)-Phenanthridinone is an inhibitor of poly(ADP-ribose)polymerase (PARP)-1 activity. The ability of 6-(5H)-phenanthridinone to potentiate the effect of ionizing radiation on tumour cells was evaluated. Action of 6-(5H)-phenanthridinone, one of the most potent PARP inhibitor, on RDM4 murine lymphoma cells in culture was evaluated.

应用

Reactant involved in:

• Synthesis of 5,6-dihydrophenanthridine sulfonamides
• Oxidative coupling with diphenylacetylene
• Direct copper acetate-catalyzedN-cyclopropylation of cyclic amides

Reactant involved in the synthesis and/or pharmacological activity of biologically active molecules including:

• Potassium channel KV1.3 and IK-1 inhibitors
• HIV-1 integrase inhibitors

包装

1 g in glass bottle

基本信息

经验(实验)分子式	C13H9NO
分子量	195.22
EC 号	213-804-3
MDL编号	MFCD00004988
PubChem化学物质编号	24858050
NACRES	NA.22

半岛bd体育手机客户端 性质

等级	technical grade
质量水平	100
mp	290-292 ℃ (lit.)
SMILES string	O=C1Nc2ccccc2-c3ccccc13
InChI	1S/C13H9NO/c15-13-11-7-2-1-5-9(11)10-6-3-4-8-12(10)14-13/h1-8H,(H,14,15)
InChI key	RZFVLEJOHSLEFR-UHFFFAOYSA-N
Gene Information	human ... PARP1(142)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)