Monoclonal Anti-Endothelin-1 antibody produced in mouse

半岛bd体育手机客户端 说明

一般描述

Endothelin consists of a family of potent vasoconstrictor peptides, which include four structurally related isoforms, ET-1, ET-2, ET-3 and vasointestinal contractor (VIC, β -ET)

特异性

The antibody shows little cross-reactivity to related peptides and no known cross-reactivity to non-related peptides.

免疫原

endothelin-1 (ET-1) conjugated to KLH

应用

Monoclonal Anti-Endothelin-1 antibody produced in mouse is suitable for immunoblotting and immunocytochemistry.It is also suitable for radioimmunoassay (RIA) at a working dilution of 1:25,000 and for immunohistochemistry at 1:250 working dilution using formalin-fixed, paraffin-embedded tissue sections.

生化/生理作用

ET-1, a 21 amino acid peptide, is produced by vascular endothelial cells. It is a potent vasoconstrictor and plays an important role in the homeostasis of the circulatory system. It is also important in pathogenesis of cardiovascular diseases. It is also involved in contraction of airway and intestinal smooth muscle. It releases vasodilator prostaglandins and nitric oxide (NO). It also plays a role in mitogenic effects on vascular smooth muscle cells and fibroblasts, stimulation of atrial natriuretic peptide secretion from atrial cardiocytes and inhibition of renin release. ET-1 is expressed in the spinal cord and dorsal root ganglia, where it may serve as a neurotransmitter/neuromodulator.

外形

Solution in phosphate buffered saline, containing 0.05% sodium azide

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号	MFCD00162279
NACRES	NA.41

半岛bd体育手机客户端 性质

质量水平	200
生物来源	mouse
偶联物	unconjugated
抗体形式	purified antibody
antibody product type	primary antibodies
克隆	TR.ET.48.5, monoclonal
species reactivity	sheep, human, rat
technique(s)	immunocytochemistry: suitable immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:250 radioimmunoassay: 1:25,000 western blot: suitable
同位素/亚型	IgG1
UniProt登记号	P05305
运输	dry ice
储存温度	?20℃
Gene Information	human ... EDN1(1906)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	nwg
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)