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一般描述

DNA damage recognition and repair factor, XPC complex subunit xeroderma pigmentosum group C (XPC) is a DNA damage recognition factor. The protein consists of 940 amino acids. The gene encoding XPC is localized on human chromosome 3p25.1 and consists of 18 exons.
XPC existsin vivoas a heterotrimeric complex with one of the two mammalian homologs ofS. cerevisiaeRad23 (HR23A or HR23B) and centrin 2.

免疫原

synthetic peptide corresponding to amino acids 922-940 of human XPC, conjugated to KLH via an N-terminal added cysteine residue.

应用

Anti-XPC (C-terminal) antibody produced in rabbit has been used in indirect immunofluorescence and western blotting

生化/生理作用

DNA damage recognition and repair factor, XPC complex subunit xeroderma pigmentosum group C (XPC) has a role in global genome nucleotide excision repair pathway. As part of the XPC complex, this protein binds to DNA sites having many lesions. Single nucleotide polymorphisms in the XPC gene have been linked to various cancers.
Defective XPC gene causes photosensitivity syndrome called xeroderma pigmentosum (XP), which is characterized by a very high incidence of light-induced skin cancer.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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