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UBE2K human

品牌
Sigma-Aldrich
货号
SRP6148
规格纯度
≥95% (SDS-PAGE)
价格
5907.32 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
UBE2K human
Ubiquitin-conjugating enzyme E2-25K kDa
LIG
HYPG
Huntington interacting protein 2
HIP2
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

UBE2K, also known as UbcH1 or E2-25K, is an E2 (ubiquitin conjugating enzyme) that is involved in the conjugation of ubiquitin to target substrates along with E1 and E3 enzymes. Once an E1 is carrying an activated ubiquitin in a ubiquitin-E1 thiolester complex, this activated ubiquitin is transferred to the active site cysteine of the E2 to form a ubiquitin-E2 thiolester complex. With the aid of an E3, the activated ubiquitin is then targeted to a specific substrate lysine. UBE2K is a biochemically important E2 due to its ability to form free K48-linked polyubiquitin chains in solution in the absence of an E3. This ability is attributed to UbcH1 possessing a C-terminal UBA domain, in addition to its E2 catalytic domain. UBE2K takes part in many cellular processes such as selective protein degradation, DNA repair, cell cycle control, and sporulation. In addition, UBE2K is involved in Alzheimer′s disease, Huntington′s disease and antigen processing through its interaction with amyloid-?, Huntington, and MHC-heavy chain proteins.

外形

75 μL of a 40 μM solution (3 nmoles) in TBS.

制备说明

Centrifuge the vial prior to opening.

基本信息

NACRES NA.32

半岛bd体育手机客户端 性质

生物来源 human
测定 ≥95% (SDS-PAGE)
形式 liquid
分子量 22.406 kDa
包装 pkg of 3 nmol
NCBI登记号 P61086
运输 dry ice
储存温度 ?70℃
Gene Information human ... UBE2K(3093)

安全信息

象形图 GHS07
警示用语: Warning
危险声明 H315 - H319
预防措施声明 P305 + P351 + P338
危险分类 Eye Irrit. 2 - Skin Irrit. 2
储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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