Boc-Asp(OMe)-fluoromethyl ketone

半岛bd体育手机客户端 说明

应用

Boc-Asp(OMe)-fluoromethyl ketone (Boc-D-fmk) has been used as a caspase inhibitor to study its effects on lactate dehydrogenase (LDH) leakage, apoptosis and virus proliferation in chorion cells , as a component of the transplantation medium for the transplantation of human embryonic stem cells (ESC)-derived medial ganglionic eminence (MGE) cells into hippocampus of mice , as a protease inhibitor to study its effects on cell death in parasites .

包装

3 mg in glass bottle

生化/生理作用

Boc-Asp(OMe)-fluoromethyl ketone (Boc-D-fmk) permits cell permeability. It is a caspase inhibitor and suppresses apoptosis induced by various kinds of stimuli. Boc-D-fmk poorly inhibits caspases-2, -5, -6 and -10.

基本信息

经验(实验)分子式	C11H18NO5F
分子量	263.26
MDL编号	MFCD03453073
PubChem化学物质编号	329773206
NACRES	NA.77

半岛bd体育手机客户端 性质

质量水平	100
测定	≥90% (TLC)
形式	solid
溶解性	DMF: soluble
储存温度	?20℃
SMILES string	COC(=O)C[C@H](NC(=O)OC(C)(C)C)C(=O)CF
InChI	1S/C11H18FNO5/c1-11(2,3)18-10(16)13-7(8(14)6-12)5-9(15)17-4/h7H,5-6H2,1-4H3,(H,13,16)/t7-/m0/s1
InChI key	MXOOUCRHWJYCAL-ZETCQYMHSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)