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位置: 首页> 品牌> Sigma-Aldrich> Valproic Acid, Sodium Salt-CAS 1069-66-5-Calbiochem

Valproic Acid, Sodium Salt-CAS 1069-66-5-Calbiochem

品牌
Sigma-Aldrich
CAS
1069-66-5
货号
676380
规格纯度
A cell-permeable, short-chained fatty acid that inhibits histone deacetylase (IC50= 400 μM for HDAC1).
价格
1090.74 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
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半岛bd体育手机客户端 名称:
1069-66-5
Valproic Acid, Sodium Salt-CAS 1069-66-5-Calbiochem
2-Propylpentanoic Acid, Na
半岛bd体育手机客户端 介绍:

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一般描述

A cell-permeable, short-chained fatty acid that inhibits histone deacetylase activity (IC50= 400 ?M for HDAC1). Induces differentiation and inhibits proliferation of cell lines derived from human malignant gliomas. At therapeutic levels (350 ?M-1.04 mM), causes inositol depletion, inhibits both GSK-3α and -3β, activates the ERK pathway, and produces neurotropic effects. Has been used as an anti-epileptic agent. Also reported to stimulate peroxisome proliferator-activated receptor (PPAR) activity. Displays a potent teratogenic activity in humans and rodent models.
A cell-permeable, short-chained fatty acid that inhibits histone deacetylase (IC50= 400 ?M for HDAC1). Induces differentiation and inhibits proliferation of cell lines derived from human malignant gliomas. At therapeutic levels (0.35 mM - 1.04 mM), causes inositol depletion, inhibits both GSK-3α and -3β, activates ERK pathway and produces neurotropic effects. Has been used as an anti-epileptic agent. Also reported to stimulate peroxisome proliferator-activated receptor (PPAR) activity. Displays a potent teratogenic activity in humans and rodent models.

包装

5 g in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
HDAC1
Product does not compete with ATP.
Reversible: no

警告

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

其他说明

Gottlicher, M., et al. 2001.EMBO J.20,6969.
Knupfer, M.M., et al. 2001.Anticancer Res.21,347.
Phiel, C.J., et al. 2001.J. Biol. Chem.276,36734.
Vaden, D.L., et al. 2001.J. Biol. Chem.276,15466.
Yuan, P.X., et al. 2001.J. Biol. Chem.276,31674.
Chen, G., et al. 1999.J. Neurochem.72,1327.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C8H15NaO2
分子量 166.19
MDL编号 MFCD00078604
NACRES NA.77

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 solid
效能 400 μM IC50
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
desiccated (hygroscopic)
颜色 white
溶解性 water: 50 mg/mL
运输 ambient
储存温度 2-8℃
InChI 1S/C8H16O2.Na/c1-3-5-7(6-4-2)8(9)10;/h7H,3-6H2,1-2H3,(H,9,10);/q;+1/p-1
InChI key AEQFSUDEHCCHBT-UHFFFAOYSA-M

安全信息

象形图 GHS07GHS08
警示用语: Warning
危险声明 H302 - H361d
预防措施声明 P201 - P202 - P264 - P270 - P301 + P312 - P308 + P313
危险分类 Acute Tox. 4 Oral - Repr. 2
储存分类代码 11 - Combustible Solids
WGK WGK 3

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