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Monoclonal Anti-β-Tubulin I+II antibody produced in mouse

品牌
Sigma-Aldrich
货号
T8535
规格纯度
clone JDR.3B8, ascites fluid
价格
2038.93 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
Monoclonal Anti-β-Tubulin I+II antibody produced in mouse
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

β-tubulin belongs to the subfamily of tubulins, which are the major building blocks of microtubules. β-tubulin has a molecular weight of 55kDa. β-tubulin structure is characterized with a core of two β-sheets enclosed by α-helices. In addition, it also contains an N-terminal domain with the guanine nucleotide-binding region, an intermediate domain with taxol-binding site and a C-terminal domain that contains the binding surface for molecular motor proteins. β-tubulin I and II is encoded by the gene mapped to human chromosome 20 and 6p25.2 respectively.
Monoclonal Anti-β-Tubulin Isotype I + II (mouse IgG2b isotype) is derived from the JDR.3B8 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from immunized BALB/c mice.

特异性

The antibody specifically recognizes an epitope located on isotypes I and II of β-tubulin. No cross-reactivity with other tubulin isotypes is observed.

免疫原

synthetic peptide corresponding to the C-terminal sequence of human β-tubulin isotype II coupled to BSA

应用

Monoclonal Anti-β-Tubulin I+II antibody produced in mouse has been used in following studies:

  • immunoblot
  • immunofluorescence technique
  • immunohistochemistry.

Monoclonal Anti-β-Tubulin I+II antibody produced in mouse has been used in:
  • enzyme linked immunosorbent assay (ELISA)
  • immunohistochemistry
  • western blotting
  • immunoblotting
  • dot blot
  • immunocytochemistry

生化/生理作用

β-1 tubulin, also known as class VI or TUBB1, plays a vital role in platelet production and is considered to be a potential biomarker candidate for immune thrombocytopenia (ITP). Mutation in the gene leads to various neuronal migration disorders such as lissencephaly, pachygyria and polymicrogyria malformations. B2702 peptide binds to β-tubulin and inhibits natural killer (NK) cell cytotoxicity and it influences microtubule polymerization, which damages cytoskeleton organization and chaperone-like activity of tubulin. Tubulin β 2B class IIb (TUBB2B)/β-tubulin II plays a vital role in migration/organization and axon guidance processes. Mutation in β-tubulin gene is associated with the development of asymmetric polymicrogyria (PMG).

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号 MFCD00145892

半岛bd体育手机客户端 性质

质量水平 200
生物来源 mouse
偶联物 unconjugated
抗体形式 ascites fluid
antibody product type primary antibodies
克隆 JDR.3B8, monoclonal
包含 15 mM sodium azide
species reactivity human, chicken, mouse, rat, bovine, pig
包装 antibody small pack of 25 μL
technique(s) indirect ELISA: suitable
indirect immunofluorescence: suitable
microarray: suitable
western blot: 1:1,000 using a chicken fibroblast extract or a chicken brain microtubule proteins preparation
同位素/亚型 IgG2b
UniProt登记号 Q13885
Q9H4B7
运输 dry ice
储存温度 ?20℃
Gene Information human ... TUBB1(81027), TUBB2A(7280), TUBB2C(10383)
mouse ... Tubb1(545486), Tubb2a(22151), Tubb2c(227613)
rat ... Tubb2(29212), Tubb2c(296554)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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