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MRS 1220

品牌
Sigma-Aldrich
CAS
183721-15-5
货号
M228
包装型号
规格纯度
solid
价格
11432.6 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
183721-15-5
MRS 1220
9-Chloro-2-(2-furanyl)-5-((phenylacetyl)amino)-[1,2,4]triazolo[1,5-c]quinazoline
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

包装

5, 25 mg in glass bottle

生化/生理作用

MRS1220 is a putative A3 adenosine receptor antagonist. MRS 1220 was found to be competitive in saturation binding studies using the agonist radioligand125I AB-MECA at cloned human brain A3 receptors expressed in HEK-293 cells. Antagonism was demonstrated in functional assays consisting of agonist-induced inhibition of adenylate cyclase and the stimulation of binding of35S guanosine 5′-O-(3-thiotriphosphate (35S GTP-gamma-S) to the associated G-proteins. MRS 1220 and MRS 1191, with KB values of 1.7 and 92 nM, respectively, proved to be highly selective for human A3 receptor vs human A1 receptor-mediated effects on adenylate cyclase. In addition, MRS 1220 reversed the effect of A3 agonist-elicited inhibition of tumor necrosis factor-alpha formation in the human macrophage U-937 cell line, with an IC50value of 0.3 μM.

特点和优势

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式 C21H14ClN5O2
分子量 403.82
MDL编号 MFCD01321046
PubChem化学物质编号 24896720
NACRES NA.77

半岛bd体育手机客户端 性质

质量水平 100
形式 solid
颜色 white
溶解性 DMSO: 2 mg/mL
2-hydroxypropyl-β-cyclodextrin: insoluble
H2O: insoluble
ethanol: insoluble
SMILES string Clc1ccc2nc(NC(=O)Cc3ccccc3)n4nc(nc4c2c1)-c5ccco5
InChI 1S/C21H14ClN5O2/c22-14-8-9-16-15(12-14)20-25-19(17-7-4-10-29-17)26-27(20)21(23-16)24-18(28)11-13-5-2-1-3-6-13/h1-10,12H,11H2,(H,23,24,28)
InChI key TWWFAXQOKNBUCR-UHFFFAOYSA-N
Gene Information human ... ADORA3(140)
rat ... Adora1(29290), Adora2a(25369), Adora3(25370)

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 Eyeshields, Gloves, type N95 (US)

Sigma-Aldrich

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