半岛bd体育手机客户端 说明
生化/生理作用
IL-5 (interleukin-5) is a maturation and differentiation factor for eosinophils. Thus, it is associated with allergy and related disorders. IL-5 association with its receptor causes activation of MEK/ERK (mitogen activated protein kinase kinase/extracellular-regulated kinase), p38 MAPK (mitogen activated protein kinase) and JAK/STAT (Janus kinase/signal transducer and activator of transcription) pathways.
Interleukin-5 is a product of activated T lymphocytes and exhibits activity on eosinophils, B cells and thymocytes. Synonyms or biological activities attributed to IL-5 include: EDF (eosinophil differentiating factor), BCGF-II (B cell growth factor-II), TRF (T cell replacing factor), IgA-EF (IgA enhancing factor) and EO-CSF (eosinophil colony stimulating factor). Natural IL-5 is a 45-50 kDa dimeric glycoprotein, although glycosylation is not required for activity. Human and mouse IL-5 exhibit homology at the nucleotide and amino acid levels and show species cross-reactivity.
外形
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.1 mg bovine serum albumin.
基本信息
MDL编号 | MFCD00163946 |
NACRES | NA.32 |
半岛bd体育手机客户端 性质
质量水平 | 200 |
生物来源 | human |
重组 | expressed in baculovirus infectedSf21 cells |
测定 | ≥97% (SDS-PAGE) |
形式 | lyophilized powder |
效能 | 0.1-0.5 ng/mL EC50 |
分子量 | 32-34 kDa |
包装 | pkg of 5 μg |
浓度 | 0.5-10 ng/mL |
technique(s) | cell culture | mammalian: suitable |
杂质 | endotoxin, tested |
UniProt登记号 | P05113 |
储存温度 | ?20℃ |
Gene Information | human ... IL5(3567) |
安全信息
储存分类代码 | 13 - Non Combustible Solids |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
个人防护装备 | Eyeshields, Gloves, type N95 (US) |
Sigma-Aldrich