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位置: 首页> 品牌> Sigma-Aldrich> SB 220025 三盐酸盐

SB 220025 trihydrochloride

SB 220025 三盐酸盐

品牌
Sigma-Aldrich
CAS
197446-75-6
货号
S9070
规格纯度
≥98% (HPLC), solid
价格
1943 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
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半岛bd体育手机客户端 名称:
197446-75-6
SB 220025 trihydrochloride
5-(2-Aminopyrimidin-4-yl)-4-(4-fluorophenyl)-1-(4-piperidinyl)imidazole trihydrochloride
SB 220025 三盐酸盐
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

应用

SB 220025 trihydrochloride may be used in p38-mediated cell signaling studies.

包装

2 mg in glass bottle
500 μg in glass bottle

生化/生理作用

SB 220025 is a potent, specific inhibitor of human p38 mitogen-activated protein (MAP) kinase, with an IC50value of 60 nM and 50- to 1000-fold selectivity. SB 220025 reduces inflammatory cytokine production and inhibits angiogenesis. SB 220025 reduced the lipopolysaccharide-induced production of TNF at an ED50value of 7.5 mg/kg. At 30 mg/kg, SB 220025 reduced the expression of TNF and inhibited angiogenesis by ~40%. In a further study, the effects of p38/CSBP MAP kinase inhibition in angiogenesis-dependent chronic inflammatory disease was tested in murine collagen-induced arthritis and SB 220025 was able to prevent the progression of established arthritis.

特点和优势

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

基本信息

经验(实验)分子式 C18H19FN6· 3HCl
分子量 447.76
MDL编号 MFCD08705333
PubChem化学物质编号 24724623
NACRES NA.77

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 solid
颜色 white
溶解性 H2O: 22 mg/mL
创始人 GlaxoSmithKline
SMILES string Cl[H].Cl[H].Cl[H].Nc1nccc(n1)-c2c(ncn2C3CCNCC3)-c4ccc(F)cc4
InChI 1S/C18H19FN6.3ClH/c19-13-3-1-12(2-4-13)16-17(15-7-10-22-18(20)24-15)25(11-23-16)14-5-8-21-9-6-14;;;/h1-4,7,10-11,14,21H,5-6,8-9H2,(H2,20,22,24);3*1H
InChI key IPFBHUGKKONHFR-UHFFFAOYSA-N

安全信息

象形图 GHS06
警示用语: Danger
危险声明 H301 - H315 - H319 - H335
预防措施声明 P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
危险分类 Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官 Respiratory system
储存分类代码 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Sigma-Aldrich

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