Monoclonal Anti-Rabbit Immunoglobulins (IgG, IgA, IgM) antibody produced in mouse

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一般描述

Monoclonal Anti-Rabbit Immunoglobulins (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Immunoglobulins are the members of the eponymous immunoglobulin super-family (IgSF). Immunoglobulins are heterodimeric proteins characterized with two heavy (H) and two light (L) chains. Based on heavy chain C domains immunoglobulins are classified in to five main classes namely IgM, IgG, IgA, IgD, and IgE isotypes.
Reacts with an epitope on the heavy chain of rabbit IgG, IgA and IgM, which is sensitive to reduction. No cross-reactivity with human IgG, IgA and IgM.

特异性

Binds only rabbit Igs. Does not react with reduced rabbit Igs.

应用

The mouse monoclonal anti-Rabbit IgG (heavy chain-specific) peroxidase conjugated antibody can be used as a secondary antibody for western blot analysis of protein preps fromE. colicultures at a concentration of 1:10000 diluted in PBSt for 1 hour at room temperature.
Monoclonal Anti-Rabbit Immunoglobulins (IgG, IgA, IgM) antibody produced in mouse has been used in enzyme linked immunosorbent assay (ELISA), immunoblots, dot blots and immunohistochemistry.

生化/生理作用

Immunoglobulins acts as a cell-surface receptor for antigen that allows cell signaling and cell activation. In addition, it also acts as a soluble effector molecule that can recognize, bind and neutralize antigens. IgG contributes to immune response including neutralization of toxins and viruses. IgM provides first line of defense and is involved in immunoregulation. IgA protects mucous membranes against toxins, virus and bacteria by direct neutralization or by prevention of binding to the mucosal membranes.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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