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Monoclonal Anti-Syntaxin antibody produced in mouse

品牌
Sigma-Aldrich
货号
S0664
规格纯度
clone HPC-1, ascites fluid
价格
6732.28 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Monoclonal Anti-Syntaxin antibody produced in mouse
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Syntaxin is a 35kD synaptic protein capable of interacting with the synaptic vesicle protein synaptotagmin. It facilitates the docking and fusion of synaptic vesicles with the plasma membrane. Monoclonal anti-syntaxin antibody can be used to screen λ gt 11 library of rat hippocampus to isolate syntaxin cDNA clones. It can also be used in microarray and immunocytochemistry. Mouse anti-syntaxin antibody reacts specifically with membrane protein syntaxin (35 kD). The product has also shown cross reactivity for rabbit, rat and bovine but not for guinea pig.
Monoclonal Anti-Syntaxin (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Syntaxin (also cited as HPC-1 antigen), a 35 kDa molecule with carboxyl-terminal membrane anchor is a synaptic protein. Syntaxin 1 is a membrane protein. Neurons express syntaxin 1A.

免疫原

synaptosomal plasma-membrane fraction from adult rat hippocampus.

应用

Monoclonal Anti-Syntaxin antibody produced in mouse has been used in:

  • immunoblotting
  • immunohistochemistry
  • immunoprecipitation from hippocampal lysate
  • immunohistochemical analysis

Monoclonal anti-syntaxin antibody can be used in immunoprecipitation and immunohistochemistry. It can also be used in western blotting. Further, this product can also be used to label monolayer cultures of neonatal retinal cells and frozen paraformaldehyde fixed tissue sections.

生化/生理作用

Syntaxin 1 (STX1A) may control exocytosis in synaptic vesicles. In retina, STX1A may help in the structural formation of the inner nuclear layer (INL) and outer plexiform layer (OPL). Deletion of STX1A in mice affects the functions of hypothalamic-pituitary-adrenal axis. It may participate in spinal nociceptive plasticity promoted by peripheral nerve injury. It has been implicated in docking at synaptic vesicles of presynaptic neurotransmitter release sites.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号 MFCD00164742
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 200
生物来源 mouse
偶联物 unconjugated
抗体形式 ascites fluid
antibody product type primary antibodies
克隆 HPC-1, monoclonal
分子量 antigen 35 kDa
包含 15 mM sodium azide
species reactivity bovine, rabbit, rat
technique(s) immunocytochemistry: suitable using monolayer cultures of neonatal retina cells
microarray: suitable
western blot: 1:2,000 using crude preparation of synaptic vesicles from rat cerebral cortex
同位素/亚型 IgG1
UniProt登记号 P32850
运输 dry ice
储存温度 ?20℃
Gene Information rat ... Stx1a(116470)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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