Anti-GABA_AReceptor (α3 subunit) antibody produced in rabbit

半岛bd体育手机客户端 说明

一般描述

GABA_Aand GABA_Breceptors differ with regard to their ionic characteristics and pharmacological properties. The GABA_Areceptor is an ionotropic receptor that forms the GABA gated chloride channel and consists of several heterogeneous subunits with membrane recognition sites for benzodiazapenes.

免疫原

peptide corresponding to amino acid residues 1-15 of human GABA(A) receptor α3 subunit. Identical in rat and mouse. Highly conserved (14/15 residues) in bovine.

应用

Anti-GABA_AReceptor (α3 subunit) antibody produced in rabbit is suitable for immunohistochemistry at a working dilution of 1:200 using rat brain frozen sections and immunoblotting at 1:200-1:300 using rat brain membranes.

生化/生理作用

The inhibitory neurotransmitter GABA signals through two distinct types of pre- and postsynaptic receptors, GABA_Aand GABA_B. Both GABA receptors can regulate depression of synaptic transmission and be involved in the inhibition controlling neuronal excitability. α3 is a subtype of GABAA receptor expressed selectively by serotonergic and GABAergic neurons. Serotonergic neurons express strong α3 immunoreactivity but, do not show any α1 immunoreactivity. On the contrary, GABAergic neurons express both α1 and α3 subunits.

外形

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, 5% sucrose and 0.025% sodium azide

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号	MFCD03455039
NACRES	NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	100
偶联物	unconjugated
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
形式	lyophilized powder
species reactivity	rat
technique(s)	immunohistochemistry: 1:200 using Rat brain frozen sections western blot: 1:200-1:300 using Rat brain membranes
UniProt登记号	P20236
运输	wet ice
储存温度	?20℃
Gene Information	human ... GABRA3(2556) mouse ... Gabra3(14396) rat ... Gabra3(24947)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable