Protein A–Biotin fromStaphylococcus aureus

半岛bd体育手机客户端 说明

一般描述

Protein A (SpA) is a 42kDa virulence factor produced byStaphylococcus aureus, and is composed of five highly homologous consecutive extracellular Ig-binding domains, namely domains E, D, A, B, and C. This protein is present in both secreted and membrane-associated forms.

特异性

Binds IgG only from most mammals, except rat, goat, and sheep

生化/生理作用

Protein A (SpA) causes B cells deathin vitro, by binding to the Fc region of antibody and the Fab regions of the B-cell receptor, thus inhibiting its opsonophagocytosis. This protein is thought to be implicated in the evasion of host immune responses byStaphylococcus aureus, and thus, might be a candidate for vaccine development approaches to prevent severeS. aureusinfections.S. aureusis responsible for nosocomial infections as well as a variety of human infections, such as food poisoning, toxic shock syndrome, endocarditis, septicemia, skin infections, soft tissue infections, and bone infections. It is also responsible for bovine and ovine mastitis. SpA typing or DNA sequence analysis of the variable repeat region of protein A gene is useful in determiningS. aureusoutbreak strains from those strains that are epidemiologically insignificant.

外形

含柠檬酸钠的冻干粉

制备说明

Prepared from P 6031, coupled to biotin by an amide bond through an aminocaproyl spacer.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号	MFCD00132098
NACRES	NA.46

半岛bd体育手机客户端 性质

质量水平	300 200
偶联物	biotin conjugate
形式	lyophilized powder
组成	Protein, ≥70% biuret
标记范围	3.0-8.0 mol biotin per mol Protein A
储存温度	2-8℃