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Doxercalciferol

度骨化醇

品牌
USP
CAS
54573-75-0
货号
1225601
规格纯度
United States Pharmacopeia (USP) Reference Standard
价格
12401.6 *本价格含增值税费
促销
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半岛bd体育手机客户端 名称:
54573-75-0
Doxercalciferol
1α-Hydroxyergocalciferol
1α-Hydroxyvitamin D 2
1α-OHD2
TSA 840
1-α-Hydroxyvitamin D2
1-Hydroxyergocalciferol
(5 Z,7 E,22 E)-9,10-Secoergosta-5,7,10(19),22-tetraene-1α,3β-diol
(5Z,7E,22E)-9,10-Secoergosta-5,7,10(19),22-tetraene-1,3-diol
度骨化醇
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一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including MSDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

Doxercalciferol is a Vitamin D2 analogue, a Vitamin D Receptor Activator (VDRA). Doxercalciferol acts as a pro-hormone, needing 25-hydroxylation in the liver for bioactivation into 1α, 25-hydroxyvitamin D2. Pivotal studies in adults on dialysis have demonstrated control of secondary hyperparathyroidism that is superior to placebo therapy, without undue suppression of 1st IMA-PTH < 300 pg/mL, or occurrences of hypercalcemia. Doxercalciferol has been shown to be effective in controlling secondary hyperparathyroidism of adult patients with CKD stages 3-4.
Doxercalciferol is a vitamin D2analog that acts as a pro-hormone, activated in the liver to 1α,25-dihydroxyvitamin D2. Despite its relatively low affinity for the vitamin D receptor (VDR) (before activation), it is effective at suppressing expression of the parathyroid hormone (PTH) gene, and appears to act through the VDR.

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

经验(实验)分子式 C28H44O2
分子量 412.65
MDL编号 MFCD00871065
PubChem化学物质编号 329749675
NACRES NA.24

半岛bd体育手机客户端 性质

等级 pharmaceutical primary standard
manufacturer/tradename USP
application(s) pharmaceutical (small molecule)
格式 neat
SMILES string CC(C)[C@@H](C)\C=C\[C@@H](C)[C@H]1CC[C@H]2C(\CCC[C@]12C)=C\C=C3\C[C@@H](O)C[C@H](O)C3=C
InChI 1S/C28H44O2/c1-18(2)19(3)9-10-20(4)25-13-14-26-22(8-7-15-28(25,26)6)11-12-23-16-24(29)17-27(30)21(23)5/h9-12,18-20,24-27,29-30H,5,7-8,13-17H2,1-4,6H3/b10-9+,22-11+,23-12-/t19-,20+,24+,25+,26-,27-,28+/m0/s1
InChI key HKXBNHCUPKIYDM-CGMHZMFXSA-N
Gene Information human ... VDR(7421)

安全信息

象形图 GHS06
警示用语: Danger
危险声明 H300
预防措施声明 P264 - P270 - P301 + P310 - P405 - P501
危险分类 Acute Tox. 1 Oral
储存分类代码 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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