Monoclonal Anti-PTEN antibody produced in mouse

半岛bd体育手机客户端 说明

一般描述

The PTEN (phosphatase and tensin homolog) gene is mapped to human chromosome 10q23. It shares sequence homology with protein tyrosine phosphatases and the cytoskeletal protein tensin.

特异性

The epitope recognized by the antibody resides within amino acids 386-403 of rat PTEN.

免疫原

synthetic peptide corresponding to the C-terminus of rat PTEN (amino acids 386-403).

生化/生理作用

The PTEN (phosphatase and tensin homolog) gene encodes a encodes a dual-specificity phosphatase that functions as a tumor suppressor by inhibiting phosphoinositide-3-kinase–protein kinase B/Akt (PI3K/PKB/Akt) signaling pathway, a crucial regulator of cell growth and survival and by negatively regulating the interactions of cell with the extracellular matrix. Mutations in this gene have been associated with several human cancers. Germline mutations in this gene have also been linked to Cowden disease (CD), Lhermitte-Duclos disease (LDD) and Bannayan-Zonana syndrome (BZS), which are characterized by increased susceptibility to tumor formation and developmental defects.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% BSA and 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号	MFCD02097285
NACRES	NA.41

半岛bd体育手机客户端 性质

质量水平	200
生物来源	mouse
偶联物	unconjugated
抗体形式	purified immunoglobulin
antibody product type	primary antibodies
克隆	PTN-18, monoclonal
形式	buffered aqueous solution
分子量	antigen ~55 kDa
species reactivity	mouse, rat, human
浓度	~1 mg/mL
technique(s)	immunocytochemistry: suitable using 4% paraformaldehyde-0.5% Triton X-100 fixation indirect ELISA: suitable microarray: suitable western blot: 5-10 μg/mL using whole extract of rat brain
同位素/亚型	IgG2a
UniProt登记号	P60484
运输	dry ice
储存温度	?20℃
Gene Information	human ... PTEN(5728) mouse ... Pten(19211) rat ... Pten(50557)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable