Monoclonal Anti-Caspase 7 antibody produced in rat

半岛bd体育手机客户端 说明

一般描述

Caspase-7 is a apoptosis-related cysteine peptidase, commonly known as CASP7. It is a human protein encoded by the CASP7 gene. CASP7 is a member of the caspase (cysteine aspartate protease) family of proteins and is an executioner protein of apoptosis.

免疫原

recombinant p20 subunit of human caspase-7.

应用

Monoclonal Anti-Caspase 7 antibody produced in rat is suitable for the following applications:

• Immunoprecipitation
• Microarray
• Western blotting at a concentration of 2-4μg/mL using a whole extract of cultured human acute T cell leukemia Jurkat cells.

生化/生理作用

Caspase-3 and -7 plays a central role in the execution-phase of cell apoptosis. The gene for caspase 7 (also known as Mch3, CMH-1 and ICELAP3) encodes a “short” prodomain protein product of 35 kDa that belongs to the Ced3/ICE family of cysteine proteases. Caspase 7 undergoes acleavage upon activation by caspase-3, -9 and -10, and granzyme B, leading to p20 and p12 subunits. It is an important intracellular effector of granzyme B-mediated apoptosis and cytotoxic Tlymphocyte- induced cell killingin vivo. Monoclonal antibodies reacting specifically with caspase 7 are useful tools for the study of protease networks involved in development and regulation and governing the life and death of cells and tissues.

制备说明

The antibody is purified from culture supernatant of hybridoma cells grown in a bioreactor.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号	MFCD01633625
NACRES	NA.41

半岛bd体育手机客户端 性质

质量水平	200
生物来源	rat
偶联物	unconjugated
抗体形式	purified immunoglobulin
antibody product type	primary antibodies
克隆	11E4, monoclonal
形式	buffered aqueous solution
分子量	antigen (full length) 35 kDa antigen (subunit) 20 kDa
species reactivity	human
technique(s)	immunoprecipitation (IP): suitable microarray: suitable western blot: 2-4 μg/mL using a whole extract of cultured human acute T cell leukemia Jurkat cells
同位素/亚型	IgG2a
UniProt登记号	P55210
运输	dry ice
储存温度	?20℃
Gene Information	human ... CASP7(840)