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位置: 首页> 品牌> Sigma-Aldrich> Anti-Synaptotagmin antibody produced in rabbit

Anti-Synaptotagmin antibody produced in rabbit

品牌
Sigma-Aldrich
货号
S2177
规格纯度
IgG fraction of antiserum, buffered aqueous solution
价格
4731.57 *本价格含增值税费
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半岛bd体育手机客户端 名称:
Anti-Synaptotagmin antibody produced in rabbit
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Synaptotagmin (Syt, p65) is an abundant synaptic vesicle (SV) membrane protein. It is characterized by a short intravesicular N-terminal domain, a single transmembrane region and two copies of highly conserved internal repeats, known as the C2A and C2B domains, which are homologous to the C2 regulatory region of protein kinase C (PKC) in the cytoplasmic domain. At least eight different isoforms of synaptotagmin (SytI-VIII) are expressed in the brain, four of which (Syt IV, V, VII and VIII) are also expressed in non-neuronal tissues.

特异性

The sequence is highly conserved among species (SytI) and is not found in other known synaptotagmin isoforms (SytII-VIII).

免疫原

synthetic peptide corresponding to N-terminus of synaptotagmin I (SytI) of rat origin (amino acids 1-16 with C-terminally added lysine), conjugated to KLH.

应用

Anti-Synaptotagmin antibody produced in rabbit has been used:

  • for cell surface labelling of synaptotagmin I (SytI)
  • in immunofluorescence microscopy
  • in western blotting

生化/生理作用

Synaptotagmin binds Ca2+phospholipids with high affinity and has a central role in Ca2+regulated neurotransmitter release. Synaptotagmin functions as a Ca2+sensor and is required for efficient exocytosis, particularly in the vesicle docking and/or fusion step with the plasma membrane. Ca2+influx triggers synaptotagmin to interact with either syntaxin or SNAP-25 and the cytoplasmic domain of neurexin leading to fusion and exocytosis. Mutations or deletion of synaptotagmin result in severely impaired Ca2+triggered neurotransmitter release. Synapses of SytI knockout mice lack the fast-component of Ca2+dependent neurotransmitter release, but exhibit no changes in the slow, Ca2+independent component of synaptic vesicle exocytosis.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号 MFCD01092496
NACRES NA.46

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 200
偶联物 unconjugated
抗体形式 IgG fraction of antiserum
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 antigen 65 kDa
species reactivity rat
technique(s) microarray: suitable
western blot: 1:5,000 using extract of rat brain membrane fraction
UniProt登记号 P21707
运输 dry ice
储存温度 ?20℃
Gene Information human ... SYT1(6857)
mouse ... Syt1(20979)
rat ... Syt1(25716)

Sigma-Aldrich

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