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位置:首页 > 品牌 > Sigma-Aldrich > Anti-Presenilin-1 (S182) antibody produced in rabbit

Anti-Presenilin-1 (S182) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
P7854
规格纯度
IgG fraction of antiserum, buffered aqueous solution
价格
5740.11 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
半岛bd体育手机客户端 名称:
Anti-Presenilin-1 (S182) antibody produced in rabbit
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Presenilin 1& 2 (PS1 and PS2) are highly homologous proteins (approx. 43-52 kD) with eight transmembrane domains. In the brain, PS1 and PS2 are expressed primarily in neurons and localized mainly in cell bodies, axons and dendrites. In non-neuronal cells, PS1 and PS2 are localized to the nuclear membrane, endoplasmic reticulum and Golgi. Presenilin 1 is located on chromosome 14.

特异性

Specific for presenilin 1 (not found in presenilin 2) and is identical in mouse, rat, and Xenopus. By immunoblotting, the antibody reacts with presenilin 1 (PS1, S182) and with the PS1 cleavage product.

免疫原

synthetic peptide corresponding to the C-terminal of human presenilin-1 (amino acids 450-467 with N-terminally added lysine) conjugated to KLH.

应用

Anti-Presenilin-1 (S182) antibody produced in rabbit has been used in:

  • immunostaining
  • immunofluorescence detection
  • immunohistochemistry
  • immunoblotting

生化/生理作用

The biological functions of the presenilin′s are yet unknown, but they are thought to be involved in protein trafficking. Mutations in the presenilin 1 (PS1) gene (>30 known pathogenic mutations) have been found in about half of the early-onset familial Alzheimer′s disease (FAD), while only two pathogenic mutations have been found in PS2.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD02097229
NACRESNA.41

半岛bd体育手机客户端 性质

生物来源rabbit
质量水平200
偶联物unconjugated
抗体形式IgG fraction of antiserum
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
species reactivitymouse, rat, human, Xenopus
technique(s)immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100 using methacarn-fixed, formic acid-treated sections of Alzheimer′s Disease (AD) brain
microarray: suitable
western blot: 1:10,000 using whole cell extract of PC12 rat adrenal pheochromocytoma cell line
UniProt登记号P49768
运输dry ice
储存温度−20℃
Gene Informationhuman ... PSEN1(5663)
mouse ... Psen1(19164)
rat ... Psen1(29192)

Sigma-Aldrich

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